cholesterol II
Terms
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Describe the structure of the 5 lipoproteins.
Lipoproteins are cholesterol coated carries of ________& _________. They have a integral _________ that determines their function -
triacylglycerols
cholesterol esters
apolipoprotien - the NIH derived desirable level for cholesterol is ____
- <200
- the NIH derived desirable level for LDL is ____
- <100
- the NIH derived desirable level for for HDL is ____
- >60
- the disease associated with increased plasma cholesterol levels is _________
- coronary heart disease
- Chylomicron carries ________ and uses apoprotien ____ to signal lipoprotein lipase activation
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dietary triglycerides
C-II - LDL carries _______ and uses apoprotien ____ to bind to the liver and other tissues
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cholesterol esters
B-100 - HDL carries _____ to the liver and uses apoprotien __ to activate LCAT, esterifies cholesterol within in plasma
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cholesterol esters
A-1 - ______ attached to LDL is a cardiac Risk Factor
- Lipoprotein A
- Patient resistant to treatment continues to have greatly increased triglycerides. What type of inherited hyperlipoproteinemia is this? What is the associated genetic disorder?
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type I
Apo C-II deficiency - Patient resistant to treatment shows normal triglycerides, but high cholesterol & LDL What type of inherited hyperlipoproteinemia is this? What is the associated genetic disorder?
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type II
LDL receptor deficiency - In class I familial hypercholesteremia (Type II) LDL receptor ______ is defective.
- synthesis
- In class II familial hypercholesteremia (Type II) processing of the receptor in the ______ is defective.
- Golgi
- In class III familial hypercholesteremia (Type II) there is a ______receptor.
- non-functional
- In class IV familial hypercholesteremia (Type II)_______ is defective
- internalization
- Describe the structure of the lipoproteins.
- Lipoproteins are cholesterol coated carries of triacylglycerols & cholesterol esters. They have a integral apolipoprotien that determines their function
- Describe Chylomicrons
- carries dietary triglycerides and uses apoprotien C-II to signal lipoprotein lipase activation
- Describe LDL
- cholesterol esters and uses apoprotien B-100 to bind to the liver and other tissues
- Describe HDL
- cholesterol esters to the liver and uses apoprotien A-1 to activate LCAT, esterifies cholesterol within in plasma
- Identify the risk factor associated with high levels of lipoprotein A.
- attached to LDL is a cardiac Risk Factor
- Identify the biochemical lab findings of Hyperlipoproteinemia Type 1 & 2
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Hyperlipoproteinemia Type 1 =high triglyceride
Type 2 =normal triglycerides, high total cholesterol and LDL - Recognize the mechanism of the Type II (Class 1-4) hyperlipoproteinemias.
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In class I familial hypercholesteremia (Type II) LDL receptor synthesis is defective.
In class II familial hypercholesteremia (Type II) processing of the receptor in the Golgi is defective.
In class III familial hypercholesteremia (Type II) there is a non-functional receptor.
In class IV familial hypercholesteremia (Type II) internalization is defective