path GI
Terms
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- name 3 types of HNPCC
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1) Lynch I=colon
2) LynchII=CUB=colon, uterus, breast
3) Muir Torre=colon, sebaceous adenoma, others - what genetic problem in HNPCC
- mutation in DNA repair gene results in dinucleotide instability
- name types non-neoplastic polyps
- inflamm (IBD), juvenile (4-6), Peutx Jegher
- what genetic mutation of FAP (chrom, gene name, inheritance)
- chrom 5, mutation in APC gene, AD
- besides GI, abd pain in Crohns could be? in UC?
- cholesterol gallstones, UC think PSC esp when jaundiced, etc
- skin manifestation in Crohns
- erythema nodosum
- PBC assoc? PSC assoc?
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PSC-UC
PBC-female, autoimmune - what part GI tract Crohn's usu involve
- term ileum, SI, colon (rectal sparing)
- risks stomach cancer
- nitrosamines, achlorhydia, chornic gastritis
- risk colon cancer
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villous adenomas, IBD, low fiber, incr age, FAP/HNPCC/FHx
+smoke??? - ab in celiac (3)
- antigliaden, antiendomysial, anti-tissue translutaminase
- risks eso cancer
- EtOH, smoke, barrette's, diverticuli, plummer-vinson, familiar
- EtOH a risk for what cancers
- eso, most H and N, HCC,
- risks uterine cancer
- estrogen, obesity, DM, HTN
- risks cervical cancer
- early sex, multiple sex partners, ?smoking? (assoc HPV 16, 18, 31, 33)