BS545-Synaptic Transmission
Terms
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- What are the three primary vesicles called?
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forebrain
midbrain
hindbrain - What are the two secondary vesicles of the forebrain?
- telencephalon and diencephalon
- What are the three major components of the diencephalon?
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Thalamus
Hypothalamus
Epithalamus - What is the primary structure in the midbrain?
- Mesencephalon
- What are the three primary structures in the hindbrain? One has an alternate name- what is it?
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Pons
Cerebellum
Myelencephalon (medulla oblongata) - What two structures are contained within the metencephalon?
- Pons and cerebellum
- What are the three major categories of neurotransmitters? A__, A__, N__
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Amines
Amino acids
Neuropeptides - Give four neurotransmitters in the amine category.
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Acetylcholine
Dopamine
Norepinephrine
Serotonine - Give three neurotransmitters that are amino acids.
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Glutamate
GABA
Glycine - Give at least three neurotranmitters that are neuropeptides.
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Angiotensin II
Substance P
Somatostatin -
Where are two major locations of neurons that emit norepinephrine.
List the corresponding locations for the terminals of each neuron. -
Sympathetic ganglia => smooth and cardiac muscle, glands.
Locus ceruleus, reticular formation => widespread CNS areas - What are the four major locations of neurons that use dopamine? Where are their corresponding terminals?
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Substantia nigra (compact part) => caudate nucleus, putamen.
Ventral tegmental area => limbic structures, cerebral cortex
Hypothalamus => infundibulum
Retina (some acrine cells) => local connections - What is the primay location of neurons that use serotonin? Where are the terminals?
- Raphe nuclei => widespred CNS areaa
- What is the mechanism involved with Lambert-Eaton myasthenic syndrome and what is affected?
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Antibodies are produced which block the entry of Ca++ ions into the motor terminals which in turn prevents the trigger of acetylcholine release.
Patient is weak. - What does botullinum or tetus toxin do to neurotransmission?
- Results in hydrolysis of one or more of the proteins required for vesicle attachment and fusion => prevents acetylcholine release.
- What is myasthenia gravis?
- A disease in which antibodies block the postsynaptic nicotinic receptors thus leading to muscle weakness.
- What is the action of curare?
- Blocks post synaptic nicotinic receptors which results in paralysis of muscles.