Bio 103 Lec 16
Terms
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- 2 types of stimuli
-
1. Lipophilic signal in cytosol/nuclear receptor
2. Lipophobic/Lipophilic: surface of cell membrane.
- Abnormal Signaling: 2 Mutations
-
1. Achondroplasia
stop differentiation; stop grwth early, short limbs (short people)
2. retinoblastoma
rapid cell divison = tumor; (tumor in eye)
- Core components of a simple extracell sig pathway (PART ii) (4)Results (3)
-
- stimulus = extracellular sig molecule
- receptor = receptor protein
- transduction = intracellular sig proteins
- effector = target proteins
Result: alter...
- metab
- gene expression
- cel - GTPase cycle (2)
-
- GTP > GDP: GAP (hydrolyzes phosphate)
- GDP > GTP: GEF (exchange nucleotide)
GTP = "ON"
- Homeostasis Example
- Body try to adapt by making RBC during high elevation
- Importance of Plasma Membrane (3)
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1. organization
2. selective permeability
3. compartmentalization
- Signal over long distnaces (2)
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- Endocrine (Bloodstream)
- Synaptic signaling (Neurotransmitters)
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Signal over short distances (4)
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- Gap Junctions
- Contact dependent
- Autocrine (acts on itself)
- Paracrine (acts locally)
- What are the core components of a simple extracellular signaling pathway? (5)
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1. signal molecule binds to
2. receptor protein which activates
3. intracellular signal molecules after
4. target proteins create
5. Response
- Why is signaling importan/needed? (3)
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- to recieve info and sense the environment to respond
- proper control of development-homeostasis.