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Mosby chapter 17


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The process by which drug molecules are moved from the site of entry into the body into the general circulation.
Of or pertaining to the sympathetic nerve fibers of the autonomic nervous system, which use epinephrine or epinephrine-like substance as neuotransmitter
Drugs that combine with receptors and initiate the expected response.
Agents designed to inhibit or counteract the effects of other drugs or undesired effects caused by normal or hyperactive physicological mecheanisms.
Of orpertaining to the blocking of acetylcholine receptors, resulting in inhibition of transmission of parasymapathetic nerve impulses
bioloical half-life
The time required to metabolized or eliminate thet toal amout of drug in the boy.
The process by which a drug is converted chemicallly to metabolite.
chemical name
The exact designation ofa chemical structrue as determined by the rules of chemical nomenclature.
Of or pertaining to the effects produced by the parasympathetic nervous system or drugs that stimulate or antagonize the parasympathetic nervous system.
Medical or physislogical factors that make it harmful to administer a medication that would other wise have a therapeutic effect.
controlled substance
Any drug defined in the categories of the comprehensive Drug Abuse Prevention and Control Act (also known as the Contorlled Substances Act) of 1970.
cumulative action
The effect that occurs when several doses of a drug are administered or when absorption occurs more quickly than removal by excretion or metabolism or both.
The transpor of a drug throught the bloodstream to various tissures of the body and ultimately to its site of action.
Any substances thaken by mothe: indjected into a muscle, blood vessel, or cavity of the body: or applied topically to treat or prevent a disease or condition.
drug interaction
Modification of the effects of one drug by the previous or concurrent administeration of another drug, thereby increasing or diminishing the pharmacological or physiological action of one or bothe drugs.
drug receptors
Parts of a cell (usually an enzyme or larege protein molecule) with which a drug molecule interacts to trigger its desired response or effect.
The elimination of toxic or inactive metabolites, primarily by the kidneys: the intestines, lungs, and mammary, sweat glands also may involved.
first-pass metabolism
The initial biotransformation of a drug during passage through the liver from the protal vein that occurs before the drug reaches the general circulation.
generic name
The official, established name assigned to a drug.
An abnormal or percuiar resonse to a drug.
loading dose
A large quantity of drug that temporarily exceeds the capacity of the body to excerete the drug
maintenance dose
The amount of adrug required to keep a desired steady state of drug concentration
official name
The name of a drug that is followed by the initials USP (United States Pharmacopeia) or NF (National Formulary), denoting its listing in one of the official publications; sually the same as the generic name
Of or pertaining to any medicaiton rout other than the alimentary canal.
The sicence of despensing drugs.
The study of how adrug acts on a living organism.
The study of how the boy handles a drug over a period of time, including the processes of absorption, distrubution, biotransforamation, and excretion.
placental barrier
Aprotective bilogical mebrane that seperaties the blood vessels of the mother and the fetus
Enhancement of the dffect of ta drug, caused by oncurrent administration of two drugs in which one drug increases the dffect of the other.
The combined effectes of two drugs that equal the sum of the idividual dffects of each agent.
The combined action of two drugs that is greater than the sum of each agent acting independently.
theapeutic action
The desired, intended action of a drug.
therapeutic index
A measurement of the relative safety of a drug.
Aphysiological response that requrires that a drug dosage be increaed to produce by a smaller dose
trade name
The trade mark name of a drug , designated by the drug company that sells the medication.
untoward effects
Side effects that prove harmful to the patient.

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