Lab Dx final
Terms
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- Iron deficiency :Peripheral smear morphology?
- microcytic, hypochromic
- Iron deficiency :MCV?
- low
- Iron deficiency :basophilic stippling?
- no
- Iron deficiency :serum iron?
- low
- Iron deficiency :TIBC?
- high
- Iron deficiency :Serum iron/TIBC?
- low <10% then definitely iron defic.
- Iron deficiency :ferritin?
- under 10, iron defic
- Iron deficiency :soluble transferrin receptor?
- increased
- Iron deficiency :absorption site?
- duodenum
- Beta Thalessemia trait :?
- Beta Thalessemia trait
- Beta Thalessemia trait :Peripheral smear morphology?
- microcytic
- Beta Thalessemia trait :MCV?
- low
- Beta Thalessemia trait :basophilic stippling?
- y
- Beta Thalessemia trait :Hgb A2 Assay?
- positive
- Alpha thalessemia trait :?
- Alpha thalessemia trait
- Alpha thalessemia trait :Peripheral smear morphology?
- microcytic
- Alpha thalessemia trait :MCV?
- low
- anemia of chronic disease :?
- anemia of chronic disease
- anemia of chronic disease :Peripheral smear morphology?
- usually normocytic, microcytic (rarely)
- anemia of chronic disease :Reticulocyte count?
- Low
- anemia of chronic disease :MCV?
- normal
- anemia of chronic disease :serum iron?
- low
- anemia of chronic disease :TIBC?
- high
- anemia of chronic disease :Serum iron/TIBC?
- >10%
- anemia of chronic disease :ferritin?
- normalish
- anemia of chronic disease :soluble transferrin receptor?
- decreased
- sideroblastic anemia :?
- sideroblastic anemia
- sideroblastic anemia :Peripheral smear morphology?
- microcytic
- sideroblastic anemia :MCV?
- low
- aplastic anemia :?
- aplastic anemia
- aplastic anemia :Peripheral smear morphology?
- normocytic
- aplastic anemia :Reticulocyte count?
- Low
- aplastic anemia :MCV?
- normal
- aplastic anemia :Marrow?
- hypoplastic
- aplastic anemia :platelets?
- low
- aplastic anemia :PMN's?
- low
- aplastic anemia :tx?
- transplant
- pure red cell aplasia :?
- pure red cell aplasia
- pure red cell aplasia :Peripheral smear morphology?
- normocytic
- pure red cell aplasia :Reticulocyte count?
- stupid low
- pure red cell aplasia :MCV?
- normal
- pure red cell aplasia :platelets?
- normal
- pure red cell aplasia :PMN's?
- normal
- pure red cell aplasia :caused by?
- dilantin, parvovirus, thymoma, PRCA
- pure red cell aplasia :tx?
- roids
- myelofibrosis :?
- myelofibrosis
- myelofibrosis :Peripheral smear morphology?
- normocytic
- myelofibrosis :Reticulocyte count?
- Low
- myelofibrosis :MCV?
- normal
- myelofibrosis :Marrow?
- fibrosis
- myelofibrosis :physcal exam findings?
- big ass spleen
- myelodysplasia :?
- myelodysplasia
- myelodysplasia :Peripheral smear morphology?
- normocytic
- myelodysplasia :Reticulocyte count?
- Low
- myelodysplasia :MCV?
- normal
- myelodysplasia :Marrow?
- variable
- myelodysplasia :iron staining?
- ringed sideroblasts
- myelophtisic anemia :?
- myelophtisic anemia
- myelophtisic anemia :Peripheral smear morphology?
- normocytic
- myelophtisic anemia :Reticulocyte count?
- Low
- myelophtisic anemia :MCV?
- normal
- myelophtisic anemia :Marrow?
- marrow replacement
- B12 deficiency :?
- B12 deficiency
- B12 deficiency :Peripheral smear morphology?
- macrocytic, multilobed polys
- B12 deficiency :MCV?
- high
- B12 deficiency :absorption site?
- terminal ileum
- B12 deficiency :foods containing nutrient?
- meat, animal products
- B12 deficiency :serum b12?
- low
- folate deficiency :?
- folate deficiency
- folate deficiency :Peripheral smear morphology?
- macrocytic, multilobed polys
- folate deficiency :MCV?
- high
- folate deficiency :absorption site?
- jejunum
- folate deficiency :foods containing nutrient?
- veggies
- folate deficiency :red cell folate?
- low
- folate deficiency :serum folate?
- low, but easily altered by one meal
- Bleeding :?
- Bleeding
- Bleeding :Reticulocyte count?
- High
- Hemolytic anemia :?
- Hemolytic anemia
- Hemolytic anemia :Reticulocyte count?
- up
- B12 deficiency due to low IF :?
- B12 deficiency due to low IF
- B12 deficiency due to low IF :schilling?
- no radioactive urine, radioactive after IF
- Normocytic anemia and low reticulocyte count :?
- Normocytic anemia and low reticulocyte count
- Normocytic anemia and low reticulocyte count :initial tests?
- Do a bone marrow aspirate and biopsy, possibly cytogenetics
- Hemolytic anemia :bilirubin?
- up (unconjugated)
- Hemolytic anemia :LDH?
- elevated (nonspecific)
- Hemolytic anemia :chromium 51 survival?
- decreased
- bleeding :bilirubin?
- no effect
- bleeding :LDH?
- no effect
- bleeding :chromium 51 survival?
- no effect
- warm IgG :?
- warm IgG
- warm IgG :intra or extra-vascular?
- extra
- warm IgG :haptoglobin?
- no effect
- warm IgG :rouleaux?
- n
- cold IgM :?
- cold IgM
- cold IgM :intra or extra-vascular?
- intra
- cold IgM :haptoglobin?
- low
- cold IgM :rouleaux?
- y
- pseudoerythrocytosis :?
- pseudoerythrocytosis
- pseudoerythrocytosis :HCT?
- up
- pseudoerythrocytosis :plasma volume?
- down
- pseudoerythrocytosis :which cell lines hyperlastic??
- none
- pseudoerythrocytosis :big spleen??
- no
- pseudoerythrocytosis :casued by high EPO?
- no
- 2ndary erythrocytosis :?
- 2ndary erythrocytosis
- 2ndary erythrocytosis :HCT?
- up
- 2ndary erythrocytosis :plasma volume?
- no effect
- 2ndary erythrocytosis :which cell lines hyperlastic??
- red
- 2ndary erythrocytosis :big spleen??
- no
- 2ndary erythrocytosis :casued by high EPO?
- yes
- polycythemia vera :?
- polycythemia vera
- polycythemia vera :HCT?
- up
- polycythemia vera :plasma volume?
- no effect
- polycythemia vera :which cell lines hyperlastic??
- red, wbc, platelets
- polycythemia vera :big spleen??
- yes
- polycythemia vera :casued by high EPO?
- EPO independent
- Pelger Huet :abnormality?
- bilobed PMN
- May Hegglin :?
- May Hegglin
- May Hegglin :abnormality?
- basophilic inclusions in WBC
- chediak Higashi :?
- chediak Higashi
- chediak Higashi :abnormality?
- giant neutrophil granules, faulty lysosmes
- Alders :?
- Alders
- Alders :abnormality?
- deep purple granules, mucopolysaccharide disorder
- Maroteaux Lamy :?
- Maroteaux Lamy
- Maroteaux Lamy :abnormality?
- Red-violet granules and lymphocyte vacuoles
- Erlichiosis :?
- Erlichiosis
- Erlichiosis :abnormality?
- ?? Caused by rickettsia, ticks
- Dohle Bodies :?
- Dohle Bodies
- Dohle Bodies :abnormality?
- 1-2 micron oval blue RER fragments
- CML :?
- CML
- CML :Anemia?
- no
- CML :RBC morphology?
- no change
- CML :WBC?
- >100K
- CML :Other cells?
- up baso's and eosinos
- CML :>5% myelocytes or younger?
- Yes
- CML :LAP?
- low
- CML :Marrow?
- myeloid hyperplasia, B&E
- CML :Splenomegaly?
- yes
- CML :t(9:22)?
- yes
- Myelofibrosis :Anemia?
- yes
- Myelofibrosis :RBC morphology?
- teardrop and nucleated
- Myelofibrosis :WBC?
- maybe up
- Myelofibrosis :Other cells?
- no change
- Myelofibrosis :>5% myelocytes or younger?
- possible
- Myelofibrosis :LAP?
- variable
- Myelofibrosis :Splenomegaly?
- yes
- Myelofibrosis :t(9:22)?
- no
- Leukemoid :?
- Leukemoid
- Leukemoid :Anemia?
- no
- Leukemoid :RBC morphology?
- no change
- Leukemoid :WBC?
- 30-40K
- Leukemoid :Other cells?
- no change
- Leukemoid :>5% myelocytes or younger?
- no
- Leukemoid :LAP?
- high
- Leukemoid :Marrow?
- myeloid hyperplasia
- Leukemoid :Splenomegaly?
- no
- Leukemoid :t(9:22)?
- no
- CLL :?
- CLL
- CLL :abnormal cell type?
- B
- CLL :CD5+?
- yes
- Mono :?
- Mono
- Mono :abnormal cell type?
- B
- Hairy cell leukemia :?
- Hairy cell leukemia
- Hairy cell leukemia :abnormal cell type?
- B
- Hairy cell leukemia :splenomagaly?
- fuckin huge
- Hairy cell leukemia :CD5+?
- no
- Hairy cell leukemia :cytopenia type?
- pancytopenia (& lymphocytosis)
- Hairy cell leukemia :diagnostic test?
- tartrate resistant acid phosphatase, TRAP
- AML :?
- AML
- AML :population?
- adult
- AML :cytopenia type?
- neutropenia, also could have elevated WBC (myeloblasts)
- ALL :?
- ALL
- ALL :population?
- children
- neutropenia :?
- neutropenia
- neutropenia :1st step in dx of host defense disorder?
- WBC and diferential
- B cell disorder :?
- B cell disorder
- B cell disorder :1st step in dx of host defense disorder?
- quantitative Ig's
- Complement deficiency :?
- Complement deficiency
- Complement deficiency :1st step in dx of host defense disorder?
- CH50, C3, if bad then quantitative C1-9
- T cell disorder :?
- T cell disorder
- T cell disorder :1st step in dx of host defense disorder?
- quantitative T and B lymphocytes, skin test to recall antigens
- early complement deficiency :?
- early complement deficiency
- early complement deficiency :infection type?
- pyogenic
- late complement deficiency :?
- late complement deficiency
- late complement deficiency :infection type?
- neisseria
- platelet problem :Physical exam findings?
- petechiae
- clotting factors :?
- clotting factors
- clotting factors :Physical exam findings?
- echymosis, joint bleeding
- vWD :?
- vWD
- vWD :Physical exam findings?
- joint bleeding
- vasculitis :?
- vasculitis
- vasculitis :Physical exam findings?
- palpable purpura
- XII and XI :?
- XII and XI
- XII and XI :what activates in PTT?
- kaolin
- disorder of: XII, XI, IX, VIII, X, V, II, fibrinogen :?
- disorder of: XII, XI, IX, VIII, X, V, II, fibrinogen
- disorder of: XII, XI, IX, VIII, X, V, II, fibrinogen :which test?
- PTT
- heparin :?
- heparin
- heparin :which test?
- PTT
- Intrinsic pathway :?
- Intrinsic pathway
- Intrinsic pathway :which test?
- PTT
- extrinsic pathway :?
- extrinsic pathway
- extrinsic pathway :which test?
- PT
- add trhomboplastin to activate VII :?
- add trhomboplastin to activate VII
- add trhomboplastin to activate VII :which test?
- PT
- kaolin to activate XII and XI :?
- kaolin to activate XII and XI
- kaolin to activate XII and XI :which test?
- PTT
- VII, X, V, II, fibrinogen :?
- VII, X, V, II, fibrinogen
- VII, X, V, II, fibrinogen :which test?
- PT
- hemophilia A :?
- hemophilia A
- hemophilia A :deficiency?
- VIII
- Hemophilia B :?
- Hemophilia B
- Hemophilia B :deficiency?
- IX (christmas disease....but it's in Jews!)
- loose fibrin :?
- loose fibrin
- loose fibrin :deficiency?
- XIII
- clotting factors :Vd?
- 40 ml/kg
- I :?
- I
- I :vitamin K??
- no
- I :PT?
- yeah (fibrinogen)
- I :PTT?
- yeah (fibrinogen)
- I :made in liver??
- yeah (fibrinogen)
- I :coumadin effects??
- no
- I :protein C & S inhibit?
- no
- II :?
- II
- II :vitamin K??
- yep
- II :PT?
- yes
- II :PTT?
- yes
- II :made in liver??
- yes
- II :coumadin effects??
- yes
- II :protein C & S inhibit?
- no
- II :cryoprecipitate?
- no
- II :prothombin complex concentrates?
- yes
- III :?
- III
- III :vitamin K??
- no
- III :PT?
- no
- III :PTT?
- no
- III :made in liver??
- no
- III :coumadin effects??
- no
- III :protein C & S inhibit?
- no
- IV :?
- IV
- IV :vitamin K??
- it's friggin calcium
- IV :PT?
- it's friggin calcium
- IV :PTT?
- no
- IV :made in liver??
- no