breast 2,3
Terms
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copy deck
- a rare maignant neo in which the smears show sheets of epi cs similar to those from fibroadenoma. fragments ofl loose but cellular connective tissue, traversed by capillaries arae evident.
- cystosarcoma phyllodes
- what % br cancer men
- 1
- a blood tinged nipple discharge usually related to-
- intraductal papilloma
- what color cyto of apocrine met on pap
- greenish-orange
- what is overall 10 yr survival rate of breast cancer
- 50%
- non-neo/smears show many anucleated squames and sq cs in an acute and chronic inflam bkgrnd
- subareolar abscess
- what cancer of fem genital tr increases risk for breast cancer
- cancer of endometrium
- what is usual diagnostic procedure once abnomality is identified to distinguish benign from malig
- biopsy
- what is cell shape of apocrine met
- large round to polygonal
- what stain other than pap for pagets dis
- wright/MGG
- the most common benign solid mammary neo
- fibroadenoma
- what stage is regional
- 2
- whaat cond of breast may ocur with history of trauma, previous surg, or radiation therapy
- fat necrosis
- is br cancer common cause of cancer death in women
- second most common
- what are reproductive factors that increase risk of breast cancer
- younger age of menarche and later menopause,nulliparity, older age at biirth of first child
- Is Ni in paget's dis cells round or mishapen
- mishapen
- geo,where is br cancer most common
- us, northern europe, then japan, taiwan
- apocrine cell
- Relating to a type of glandular secretion in which the apical portion of the secreting cell is released along with the secretory products.
- in what pop are the majority of br cancers
- postmenapausal
- which stage is disseminated disease
- 4
- describe cells in aspiration of paget's disease of br
- usually large,round hyperchromatic N and promNi
- how does genetics affect risk of breast cancer
- individual risk increases with greater no of affected first deg relatives, younger age onset, and bilateralilty. High risk in some families. Li-Fraumeni syndrome
- most common of all breast lesions(benign or malig,solid or cystic)
- breast cyst
- % women affected by fibrocystic changes
- 10%
- what individual factors increase risk factor for breast cancer
- atypical ductal or lobular hyperplasia, contralateral breast cancer, cancer of endometrium
- survival rate stage 4
- 10% 5 yr survival
- 10 benign breast neoplasms
- SUBAREOLAR ABSCESS,FIBROADENOMA,FIBROCYSTIC CHANGES,DUCTAL HYPER-PAPILLAMATOSIS,INTRADUCTAL PAPILLOMA,PAGEEET'S DISEASE,INTRAMMARY LYMPH NODE,FAT NECROSIS,APOCRINE MET,BREAST CYST
- 3 possible causes of nipple discharge
- systemic neuroendocrine disorders,lesions within breast as intraductal papillomas,lactational changes induced by tranq drugs or oral contraceptive
- what are ducts lined by
- cuboidal or low columnar epi and outer layer of myoepithelial cells
- percentage of women who will get br cancer
- 1 in 9
- malignant neo/smears thick with abundant pink mucoid material(brownish on pap) traversed by branching capillaries. the neooplastic cells may be arranged in tight clusters lacking N atypia. they may also be arranged in sheets or singly with cyto vacs of aried sizes, and slight to mod variaation in N size and shape
- colloid carcinoma
- describe involvement of all 4 stages br carc
- stage1-LOCALbreast only/stage2 REGIONAL no distant met mobile oxillar lymph node/stage3 ADVANCED REGIONAL-no dist met llymph,skin,chest wall pectoral muscle involstage4 FULL BLOWN BOTH SIDES-distant met, lymph node involvem
- 6 risk factors for br carc
- 1.GEOGRAPHY/2.GENETICS/3.INDIVIDUAL --FACTORS - atypical hyper , endomet carc/endocrine-obessity,estrogen sups or obesity/diet/ENVIRO,-smokingDIET-high fat REPRODUCTIVE FACTORS-multiparity,older at first birth,early menarche, late menapause
- what color cyto of apocrine met on hematologic stain
- grayish pink
- survival rate stage2
- 65% 5 yr surv
- name epi that lines distal sinuses of br
- kert.sq epi?
- describe cytologic appearance of a cell from apocrine met-cell shape, N Ni, cyto
- cell shape is large, round or p olygonal/Nround/ Ni prom/cyto-abundant( grayish pink with hematologic stain/green-orange on pap)
- whaat is 5 yr survival rate for stage 1
- 80%
- what is it generally assumed that paget's disease of the br is due to
- infiltration of sq epi of nipple by carc cs derived from underlying intraductal or infiltrating carc
- non-neo/smears varied pop of mature lymphocytes,immunoblasts,plasma cells,histeocytes(some with ting bods) and lylmphoid tangles
- intramammary lymph node
- 5 yr survival rate stage 3
- 40%
- what is usual age for fibrocystic change
- 30's and 40's
- malignancy assoc with paget's disease of br
- ductal adeno-in situ or infiltrating
- name and explain the four stages of br carc
- STAGE 1-localized ,less than 2cm,limited to breast-80%,5yr survival/STAGE 2-regional, less than 5 cm, with involved but mobile oxillary lymph nodes,or tumor more than 5 cm with regular nodes. no distant mets-65% 5 yr survival/STAGE 3 advanced regional disease, tumor involving pectoral muscles or chest wall;fixed involved lymph nodes,no distant met 40% ,5 yr survival/STAGE 4 distant mets, including ipsilateral,supraclavicular lymph node-10% 5 yr survival-Full blown-both sides
- a benign neo in which smeaars extremely cellular. the ei cells are arranged in sheets with honeycomb appearance and in irreg clumps and clusters with blunt branching(staghorn). the small hyperchromat N of myoepithelial cells are scattere through the sheets and clusters of epi cells. Many bipolar N are seen in bkgrnd
- fibroadenoma
- name neoplasm related to blood-tinged nipple discharge
- intraductal papilloma
- other than stage what are prognostic factors of br cancer
- grade-(well,mod or poorly diff),steroid hormone(estrogen,progesterone)receptors, growth rate, oncoagene expression, invasive potential(evidence of lymphatic or vascular invasion
- 3 cellular elements frequently found in breast aspirates
- bipolar naked n,fibroadipose tiss,ductal cells
- non-neoplastic process in which smears exhibit sheets(monolayers),often folded,composed of regular ductal cells and occasional myoepithelial cells. Clumps of ductal cells with glandular lumina in their centers and irreg borders with fingerlike projections are also present. Stripped N may be present
- ductal hyperplasia-papillamatosis
- does the incidence of br cancer risk increase with age
- yes
- 8 malignant neoplasms of breast,
- ductal adeno(NOS), ductal cell carcinoma with sq diff, lobular, colloid,apocrine cell carcinoma. mucus cell,cytosarcoma phylloides, medullary carcinoma
- what is connection of menstrual cycle on fibrocystic change
- may wax and wane with cycle
- is br cancer decreasing
- no increasing
- what are dietary and enviromental risk factors
- high fat diet, moderate alcohol consumption, smoking and side-stream smoke, enviromental toxins, pesticides
- which stage is localized
- 1
- describe Ni of apocrine met
- prominent
- 6 cellular elements found in br aspirates
- ductal cells/apocrine met cells/stripped naked bipolar n/myoepithelial cells/histeocytes/fibroadipiose tiss
- do oral contraceptives increase risk of breast cancer
- no apparent risk
- what is most important predictor of outcome
- stage-determined by size and exent
- what are 7 risk factors in br cancer
- geography,genetics, individual factors, reproductive factors, endocrine, diet and enviromental
- the ducts of the br are lined by what epi
- cuboidal or columnar
- a malignant neo in which smears display enlarged, irreg naked N with prom Ni. It is important to differentiaate these cels from malignant lymphoma. many lymphocytes,histiocytes, and p lasma cells are observed surrounding the epithelial cell clusters and in the background
- medullary carcinoma
- in what age group is br cancer uncommon
- under 25
- 3 collection methods for br cytology
- scraping of nipple/nipple secretions(discharge),FNA
- the outer layer of br ducts is layer of------
- myoepithellial cells
- describe cytologic pic of benign breast cyst-at least 3 components
- amorphous debrit/leukocytes/a few macrophages/clusters of ductal cells with small regular n and scanty cyto/some groups ductal cells with appocrine met
- what must be present for adequacy in br aspirate
- fibroadipose tiss
- non-neo smears with bubbly appearance due to inumeraable lipid laden macs with abundant vacuolaated cyto. may be caused by jogging and aerobic excercise withour support
- fat necrosis
- what are endocrine factors that increase risk of breast cancer
- estrogen suppliments,obesity
- which stage is advanced regional disease
- 3
- 5 yr survival rate ppercentages of 4 stages br carc
- stage one 80%/stage2-64%/stage3-40%/stage4-10%
- what carcinoma accounts for 75% of all br cancers
- ductal
- malignant neoplasm that may be interpreted as unsat by inexperienced. scant cellularity. small gps of loosely cohesive cells with scant cyto and enlarged irregular N,whaich are sometimes attached to p ale pink fibrocollagenous tissue
- lobular carcinoma