Glycogen Metabolism
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- 2 roles of glycogen are:
- buffer blood glucose levels and provide a means of storing glucose for strenous muscular activity
- In muscle cells, glucose 6 P does what?
- feeds directly into glycolysis
- In liver, glucose-6-P does what?
- Uses Glu 6 Phosphatase to directly release glu. into bld.
- Cleavage of alpha 1,4 glycosidic bonds is by?
- glycogen phosphorylase
- What enzyme shifts 3 residues to acceptor branch?
- transferase
- What enzyme hydrolyzes the single remaining glucose?
- alpha 1,6 glucosidase
- What converts glu 1-P to glu 6-P?
- phospho glucomutase
- What releases free glucose into the blood after glycogen breakdown?
- glucose 6 Phosphatase
- Biosyntheses of glycogen requires what?
- UDP - glucose
- Enzyme used to catalyze UTP + glucose 1 P to UDP glucose is?
- udp glucose pyrophophorylase
- formation of alpha 1,4 glycosidic bond is catalyzed by?
- glycgen synthase
- what enzyme primes the chain by adding four residues?
- glycogenin
- glucosyl units are added to what end of the growing glycogen chain?
- non reducing termini
- what enzyme allows for branching of glycogen?
- branching enzyme
- Why do we need it branched?
- Inc. solubility and faciliate the rate of degradation and synthesis
- What are the requirements for the branching enzyme
- moves groups of 7 residues from a chain at least 11 subunits long. New branch pt has to be at least 4 positions away from its nearest neighbor.
- WHy is processs so precise?
- allows for less enzymes for degradation and synthesis.