phospholipid metabolism
Terms
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- Structure of glycerophospholipids
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Glycerol w/ fatty acid at C1 and C2
exchange group at phosphate - phosphatidic acid
- beginning structure. Add to phosphate -OH to change into other glycerophospholipids.
- Licithin
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Phosphotydalcholine
need to produce surfactant.
w/ dificiency get dermatitus
can get arachadonic acid from - phosphotidylinosital
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used in signal transduction.
broken down by Phospholipase C to form IP3 and DAG.
synthesis inhibited by lithium. contains arachadonic acid. - production of phosphotidylinositol, cardiolipin, phosphatidylglycerol
- CTP-diacylglycerol is formed and binds glycerophospholipid.
- production of phsphtidyl- choline, ethanolamine, serine
- CTP binds head group, then combines with diacylglycerol and phospholipid
- cytodine nucleotide
- CTP is used to activate headgroups and DAG. CMP is released from reaction
- Colleen Lakker
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respiratory distress syndrome
6 week premature infant
not enough sufactant(surface tension) - Red Scaly dermititis
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happens with choline deficiency
need 550 mg/day men
425 women
happens with total parenteral nutrition - Total parenteral nutrition
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leads to choline dificiency
red scaly dermititus - Phospholipase A1
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present in many tissues
removes FA from C1 - Phospholipase A2
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present in many mammalian tissues and pancreatic tissues
relases archodonic acid from phosphotidylinositol
is a proenzyme, and activated by trypsin
inhibited by glucocorticoids - cortisol/glucocorticoids
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inhibits Phosphoipase A2.
stops release of arachodonic acid - Phospholipase C
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found in liver lysosomes and alpha toxin of clostridia and other bacilli
activated by the PIP2 system
plays a role in signal tranduction
produces IP3 and DAG from PIP2
cleaves the phosphate group - phosphotidylinositol/second messenger
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PIP2 is cleaved by phospholipase C to produce IP3 and DAG.
IP3 binds with ER to cause release of Ca
Ca activates protein kinase C and DAG enhances activity
causes phosphorylation cascade - Litium
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inhibits the production of phosphotidylinositole
inhibits the production of inisitol myo - Phosphotidylinositole degradation and recycling
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inhibited by lithium
DAG to phosphotidic acid then activated with CTP
IP3 is converted to inositole myo