Pharmacology I Exam I terms
Terms
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- Labetalol
- Nonselective alpha and beta antagonist
- Carvedilol
- Nonselective alpha and beta antagonist
- Phenoxybenzamine
- Nonselective alpha antagonist
- Phentolamine
- Nonselective alpha antagonist
- Prazosin
- Alpha1 antagonist
- Terazosin
- Alpha1 antagonist
- Doxazosin
- Alpha1 antagonist
- Indoramin
- Alpha1 antagonist
- Rauwolscine
- Alpha2 antagonist
- Yohimbine
- Alpha2 antagonist
- Tolazoline
- Alpha2 antagonist
- Propranolol
- Nonselective beta antagonist
- Pindolol
- Nonselective B1 and B2 blocker with intrinsic sympathomimetic activity (ISA) (partial agonist) Leads to less beta receptor up-regulation and less supersensitivity
- Timolol
- Nonselective B1 and B2 blocker
- Penbutolol
- Nonselective beta antagonist
- Nadolol
-
Nonselective B1 and B2 blocker
Not readily metabolized
T1/2 = 14-24 hr
Once daily dosing is possible
No significant CNS effect - Carteolol
- Nonselecive beta antagonist
- Sotalol
- Nonselective beta antagonist
- Acebutolol
- Beta1 antagonist
- Betaxolol
- Beta1 antagonist
- Esmolol
- Beta1 antagonist
- Atenolol
- Beta1 antagonist
- Celiprolol
- Beta1 antagonist
- Metoprolol
-
B1 50-100 > B2
T1/2 = 3-5 hr
Fewer side effects
Decreases renin release - Butoxamine
- Beta2 antagonist
- Isoproterenol
- Nonselective beta agonist
- Xamoterol
- Beta1 agonist
- Metaproterenol
- Beta2 agonist
- Fenoterol
- Beta2 agonist
- Terbutaline
- Beta2 agonist
- Salbutamol
- Beta2 agonist
- Ritodrine
- Beta2 agonist
- Salmeterol
- Beta2 agonist
- Formoterol
- Beta2 agonist
- Pirbuterol
- Beta2 agonist
- Bitolterol
- Beta2 agonist
- BRL 37344
- Beta3 agonist
- Oxymetazoline
- Nonselective alpha agonist
- Xylometazoline
- Nonselective alpha agonist
- Tetrahydrozoline
- Nonselective alpha agonist
- Phenylephrine
- Alpha1 agonist
- Metaraminol
- Alpha1 agonist
- Methoxamine
- Alpha1 agonist
- Clonidine
- Alpha2 agonist
- Guanabenz
- Alpha2 agonist
- Guanfacine
- Alpha2 agonist
- Rilmenidine
- Alpha2 agonist
- Moxonidine
- Alpha2 agonist
- Alpha-methyldopa
- Alpha2 agonist
- Propanolol
-
Nonselective B1 and B2 blocker
Large first pass effect
T 1/2 = 3-5 hr
Some CNS effects
First used as antiarrhythmic agent - Labetolol
-
Nonselective B1 and B2 plus a1 blocker
Beta:alpha block is 3:1
Beta blockade occurs at lower doses
Alpha plus beta blockade is good for treatment of pheochromocytoma - Carvediolol
- S(-) isomer or racemic mixture exhibits non-selective beta blockade while the R(+) exhibits alpha blockade.
- Bisoprolol
-
Selective B1 blocker
B1 selectivity is not absolute so that B2 activity occurs at doses above 20 mg.