Bio Chem Pkt 4-5-6
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- What are two things that inhibit thymidylate and what does it do?
- 5-fluorouracil and methotrexate- its for new DNA for newly dividing cells
- what are the two AA associated with Trasnsportation of H?
- BHis 146 and BAsp 94
- nothing
- notihing
- exergonic
- energy releasing
- Fxn of Lispro and Aspart
- prevent hexamer formation- bc hexamer slow down diffusion of insulin into circulation= faster and shorter duraton
- What are zocor and lipitor used for and how do they do it?
- Lower cholesterol by inhibiting HMG-CoA reductase
- What do MMps do?
- remodel extracelluar matrix- wound healing cell migration, new blood cells growth
- What does the change in HBf allow for?
- HbF to pick up oxygen from mother bc has a high affinity bc 23bpg wanted to prevent the binding of o2
- Rx name for Aspart insulin
- Novolog
- What does the inhibition of ACE do?
- prevents cleavage of angio tensin1 to angiotensis 2
- What does streptokinase do?
- activiates plasminogen to convert to plasmin
- What are the 3 strands of collagen triple helix held together by?
- h bonds btween 4hydroxproline and 2hydroxlylysine
- What is present in alzhimer patient's brain?
- B-amyloid plaques- tangle protien fibers
- What are the two aminotransferases that increase with liver damnaged shown on LFTs?
- ALT (alanine aminotransferase) AST (aspartate aminotransferase)
- what are the two his on the hem ring?
- His 64 and His 93
- What happens as you stablized the T form?
- give off oxygen
- How does penicilin inhibit?
- Inhibits an enzyme responsible for key step in production of bacteral cell wall.
- What type of protease is tPA?
- serine protease
- wat does it mean that Hb has such a high p50?
- it takes a lot more o2 pressure in surround to half saturate HB
- What will amino acid composition destroy?
- Ser, Thy, Tyr, Trp, Gln, Asn
- What role do MMps play in cancer?
- expressed in higher amounts and enable cancer cells to spread
- what happens as pH increases?
- Hb bind o2 tightly
- What does 2,3 BPG stablize?
- the T state- therefoer gives off oxygen
- What type of protease is plasmin?
- serine protease
- What are three things used to clear blood clots?
- Streptokinase and tPA (tissue plaminogen activator and plasmin
- Wat is replace in HBf?
- BHis 143 replaves with Serine
- Where is there high 02 pressure
- in the lungs
- as you age what happens to the cross linking?
- more croslinking
- What plays a key role in rheumatoid arthrisit??
- MMPs by breaking down too much cartliage
- What characteristics are in the lungs?
- Higher pH- binds o2 relase H
- What stablization rxn occurs btw His ___?
- His 146 interacts with B Asp 94
- What does plasmin do?
- cleaves the insoluble fibrin into soluble componets
- What does Captopril do?
- its an ACE inhibitor
- What happens as Co2 increase?
- Hb releases o2
- What happens are you stablized the R state?
- bind oxygen
- What is the result of wat penicilin does?
- the weak cell wall of bacteria can't hold up against osmotic prssure so it blows up
- Where are hys 64 and his 93 located?
- on the heme ring
- what is so bad about angiotensin 2?
- ptotent vasoconstrictor
- What is fibrin
- the stuff that clots are madfrom
- What are the other AA and # in HB?
- His2 His143 Lys82
- What does the graph of Mb say?
- that it saturates real quick and binds o2 real tight
- What are the AA associated with Transport of Co2?
- Arg141 and carbamate
- Rx name for Lispro insulin?
- Humalog
- What increase HbS in deoxy form?
- high altittudes, increase Co2, descrease pH (excerzie) increase 23Bg
- What was the first protien for which the entire strucure was deteminded by xray crystallography?
- Mb