Autoantibodies and disease
Terms
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- Antinuclear antibodies (ANA)
- SLE
- Anti-dsDNA
- specific for SLE
- Anti-Smith
- specific for SLE
- Anti-histone
-
specific for drug-induced lupus
(caused by:
Hydralazine, INH, Phenytoin, Procainamide) - Anti-IgG
- Rheumatoid arthritis (autoantibody also known as rheumatoid factor)
- Antineutrophil
- Vasculitis
- p-ANCA
-
Polyarteritis Nodosa
1. necrotizing degeneration of media --> aneurysms
2. small and med arteries
3. ass'd w/ Hep B - c-ANCA
-
Wegener's Granulomatosis
1. necrotizing, granulomatous lesions in kidney and lung
2. small arteries and veins
3. cough, ulcers of nasal septum, RBC casts - Anticentromere
-
Scleroderma (CREsT)
Calcinosis
Raynaud's
ESophageal dysfn
Telangiectasia - Anti-Scl-70
- Scleroderma (diffuse)
- Antimitochondrial
- Primary Biliary Cirrhosis (PBC)
- Antigliadin
- Celiac sprue
- Anti-basement membrane
- Goodpasture's Syndrome
- Anti-epithelial cell
- Pemphigus vulgaris
- Antimicrosomal
-
Hashimoto's thyroiditis
(anti-thyroglobulin and anti-thyroid peroxidase)