antidperessants
Terms
undefined, object
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- TCAs
-
amitriptyline
nortiptyline
imipramine
desipramine
clomipramine - SSRI
-
fluoxetine
sertraline
paroxetine
fluvoxamine - mechanism of action of antidepressants
- inhibition of uptake of 5-HT and or NE
- production of cardiac side effects of TCA is due to
- blocaked of ion channels like VANaC
- theraputic doses of TCA produce side effects:
-
sedation
insomnia
tremor - higher doses of TCA produce side effect:
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orthostatic hyptension
reflex tach
direct cardiac toxicity
cholinergic blockade
weight gain - used for OCD
- clomipramine
- ipramine or triptyline suffix
- TCA
- fluoxetine
-
prototypic SSRI
no alpha 1 adrenergic, muscarinic, or histaminergic activity
no effect on cardiac contractility and conduction
cns active, lipid soluble
long half life - side effects of SSRI
- nausea, insomnia, sexual,
- possible effect of combining SSRI with MAOI
- serotonin syndrome
- which is more effective at treating severe depression SSRI or TCA
- TCA
- which produces no hypotension, weight gain, sedation, anticholinergic or significant cardiac SE... SSRI or TCA
- SSRI
- which has a larger therapeutic index... SSRI or TCA
- SSRI
- venlafaxine
- SNRI
- reboxetine
- NRI
- buproprion
-
atypical AD
related to amphetamine/releases SA
stimulant
effective in depression assocaited with psychomotor retardation - AD used to treat nicotine withdrawel
- buproprion
- MAOIs
-
phenelzine
tranylcypromine - drug interactions with MAOI
-
wine and cheese syndrome
sympathomimetic amine
serotonin syndrome with SSRI - serotonin syndrome
-
MAOI plus SSRI
hyperthermia, muscle rigidity, myoclonis - which antidepressent suppresses REM sleep and can be used in narcolepsy
- MAOI
- Li
-
mood stabilizing drug
inhibits activity of phosphatase that hydrolyzes inositol 2 or 1 phosphate, depleting the stores of PIP2
reducing the effect of transmitters and hormones that act by activating PLC - excretion of lithium is lowered by what?
-
anything that causes promotion of Na reabsorption by kidney (na restriction, water depletion, hypovolemia, duretics)
Li eliminated by kidney and reabsorped in proximal tubule - uses of lithium
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manic episode acute treatment
prophlaxis of manic depressives - alternative to lithium
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carbamazepine
valproate - valproate
- alternative to Li
- carbamazepine
- alternative to Li
- tyramine
-
intereacts with MAOI to produce wine and cheese syndrome
indirectly acting sympathomimetic amine - ephedrine
-
interacts with MAOI
wine and cheese syndrome
indirectly acting sympathomimetic amine