IPC 6 Antidepressants
Terms
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- Amitriptyline (Elavil)
- inhibit reuptake of serotonin and norepinephrine at the presynaptic terminus, also have anticholinergic properties via blockade of muscarinic receptors, and may have some alpha-1-adrenergic and H1-receptor blockade
- Bupropion (Wellbutrin)
- Norepinehprine and dopamine reuptake inhibition (no effect on serotonin)
- Citalopram (Celexa)
- Seritonin reuptake inhibitors. Minimal effect on NE reuptake and minimal effect on muscarinic receptors, thus giving SSRIs a better side effect profile and making it superior to TCAs
- Clomipramine (Anafranil)
- most serotonin specific of the Heterocylcic agents (HCAs)
- Desipramine (Norpramin)
- least anticholinergic of the HCAs
- Doxepine (Sinequan)
- antihistaminergic and anticholinergic
- Duloxetine (Cymbalta)
- inhibiting CNS reuptake of serotonin and NE
- Es citalopram (Lexapro)
- Most serotonin specific of the SSRIs
- Fluoxetine (prozac)
- See Citalopram
- Fluvoxamine (Luvox)
- Inhibition of the serotonin reuptake pump. Causes an increased concentration of synaptic serotonin.
- Imipramine (Tofranil)
- Inhibit the re-uptake of norepinephrine, dopamine, and/or serotonin. May also effect H1 and muscarinic receptors. Response takes 2-4 weeks.
- Mirtazapine (Remeron)
- Blocks pre-synaptic alpha-2 receptors (normally inhibit the release of norepi and serotonin). Mirtazapine also blocks the post synaptic 5HT-2 and 5HT-3 receptor.
- Nefazodone (Serzone)
- Blocks post synaptic 5HT-2 receptors, presynaptic serotonin reuptake pump, and presynaptic norepinephrine reuptake.
- Nortriptyline (Pamelor)
- Prevents the reuptake of 5HT and NE into the presynaptic neuron by blocking reuptake transporters. Does not effect dopamine reuptake.
- Paroxetine (Paxil)
- Reversibly blocks the reuptake of serotonin into the post-synaptic neuron.
- Phenelzine (Nardil)
- Inhibits monoamine oxidase, preventing the destuction of dopamine, serotonin, and norepeinephrine. This provides more available neurotransmitters for synaptic transmission.
- Protriptyline (Vivactil)
- Blocks the reuptake of 5HT and NE from the synaptic cleft by reuptake transporters. Does not effect dopamine reuptake.
- Sertraline (Zoloft)
- selective presynaptic 5-HT reuptake - weakly affect NE & dopamine neuronal uptake
- Tranylcypromine (Parnate)
- nonhydrazine monoamine oxidase inhibitor - inc endogenous conc of Epi, NE, dopamine, and 5-HT via stoping presynaptic breakdown
- Trazodone (Desyrel)
- Inhibits reuptake of serotonin - acts as an agonist at higher doses and antagonizes serotonin at low doses. Sedation due to alpha-adrenergic blocking and histamine blockade
- Venlafaxine (Effexor)
- inhibit 5-HTand NE (dopamine weakly too)