medchem MOA anticancer
Terms
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- most reactive AA? spontaneously reacts
- mechlorethamine
- dec. uptake by choline transport (resist)
- mechlorethamine
- give N-acetylcysteine to help bladder tox?
- cyclophosphamide
- mechlorethamine analogs?
- melphalan, chlorambucil
- palliative Tx?
- thiotepa
- intravesicle injection to bladder?
- thiotepa
- for Hodgkin's?
- mechlorethamine, vincristine, L/C
- only monofunctional?
- L/C
- for bone marrow tranplants?
- busulfan
- spontaneously reacts with water & DNA bases & proteins?
- L/C
- forms x-links and monoadducts?
- cisplatin
- what sort of ion transfers a alkyl group to a macromolecule?
- carbonium ion (AA)
- what do AA attack?
- nucleophils (with (-) charges)
- avoid aluminum equipment?
- cisplatin
- resist: inc. GSH, inc. DNA repair enzymes
- cisplatin