Antianginal Agents
Terms
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- Types of antianginal agents
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-nitrates
-beta blockers
-calcium channel blockers - What causes angina pectoris?
- When the supply of oxygen and nutrients in the blood is insufficient to meet the demands of the heart
- Types of angina
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-chronic stable angina
-unstable angina
-vasospastic angina - Therapeutic pbjectives of antianginal agents
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-increase blood flow to
ischemic heart muscle
-decrease myocardial o2 demand
-prevent or delay the worst poss. outcome (MI) - Nitrates do what?
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Cause vasodialation due to relaxation of smooth muscles
-Dialate coronary arteries - Nitroglycerin is used for...
- ...IV form is used for BR control in perioperative hypertension, tx of CHF, ischemic pain, and pulm. edema associated with MI
- Two common Beta Blockers
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-Lopressor
-Inderal - Beta Blockers Mech. of Action
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Decr. HR, resulting in decr. myocardial o2 demand and incr. o2 delivery to heart
Decr. contractility - Beta Blocker side effects
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bradycardia, hpyotension, 2nd or 3rd degree heart block
Altered glucose and lipid metabolism - Name a Calcium Channel Blocker
- Procardia
- Calcium Channel Blockers mech of action
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cause peripheral arterial vasodilation
Result: decreased myocardial o2 demand - Calcium Channel Blocker therapeutic uses
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-1st line agents for tx of angina, hypertension and supraventricular tachycardia
-Short term mgmt of a-fib and flutter - Patients taking beta blockers should...
- ...monitor pulse rate daily and report any rate lower than 60 bpm