anti fungals
Terms
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- amphotericin B
-
broad spectrum
lifethreatening infections aspergillus meningitis
iv liposome suspension
Cytolytic pore forming via erosterol binding
renal impairment!
decreased[K] - Nystatin
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cytolytic ergosterol
topical for candida - Flucytosine
-
Bone marrow toxicity
inhibits RNA DNA synth
combo for menigitis and blastomycoses - Griseofulvin
-
interaction with warfarin
fungistatic micritubule inhibition
PO for dermatophytes - Ketaconazole
-
affects steroid synth and p450
PO mucous candida
blocks ergosterol synth - Miconazole/Clotrimazole
-
topical candida dermatophytes OTC
Blocks ergosterol synth - Intracinazole
-
block of ergosterol
po no csf penetration
potent for systemic infections of aspergillus dermatophytoses - Fluconazole
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CSF penetration
cryptococcal meningitis
blocks ergosterol - Verconazole
-
blocks ergosterol
csf penetration
meningitis andpergillus and candida -
Terbinafine
Naftifine -
cutaneous mycoses not candida
nail infections
inhibits squalene matebolism - Caspofungin
-
invasive candidiasis
blocks cell wall synth
candida and aspergillus