Anti-convulsants pharmacology
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- What should pregnant women be on if on anti-convulsants?
- folic acid supplement
- Where are most AEDs metabolised?
- liver
- What do Benzodiazepines do to GABA-mediated Cl- channels?
- inc frequency of opening
- What do barbiturates do to GABA-mediated Cl- channels?
- prolong opening
- What do barbiturates do to voltage-dependent sodium channels?
- blocks them
- What channel is associated iwth absence seizures?
- t-type Ca currents
- How does Gabapentin work?
- GABA reuptake inhibitor
- How does Tiagabine work?
- GABA reuptake inhibitor
- How does Phenytoin work?
- Na blocker
- How does Carbamazepine?
- Na Blocker
- How does oxcarbazepine?
- Na Blocker, K channel augmentor
- How does zonisamide work?
- Ca channels T type
- How does ethosuxamide work?
- thru Ca channel T tyoe
- How does Falbamate work?
- thru Na channels
- How does lamotrigine work?
- Na Channels, maybe glutamate, maybe Ca
- How does topiramate work?
- inc frequency of GABA, Ca, Na
- How does valproate work?
- Inc GABA, Block Na, Augment K, Maybe T type Ca
- Which drug causes erythemia multiforme?
- phenytoin
- What is Steven-Johnsons Synd?
- Erythema multiforme with muscosal involvement due to phenytoin
- What are the ADR of Carbamazepine?
- hyponaturemia and agranulocytosis
- Which drug is autostimulatory of its metabolism?
- carbamazepine
- What are the ADR of phenobarbital?
- CNS sedation, rash, tolerance, addiction
- What is primidone?
- a barbituate
- How does primidone work?
- thru prolonging GABA mediate Ca channels
- Which drug causes paradoxycal hyperexcitability in children?
- benzodiazepines
- Which drug causes a potentially life-threatening dermatitis?
- lamotrigine
- Which drugs stim CYP enzymes?
- Barbiturates, phenytoin, carbamazepine
- Which drugs both inhibit and stim CYP enzymes?
- oxcarbazepine, felbamate, topiramate
- Which drug inhibits P450s?
- valproate
- Which two drugs cause aplastic anemia?
- felbamate, carbamazepine