Pathophys
Terms
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- Factors Affecting GFR
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Changes in renal blood flow
Changes in afferent arteriolar diameter
Changes in efferent arteriolar diameter
Changes in perfusion pressure
Contraction of glomerular mesangial cells - Why do we need such a high GFR?
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Wastes are generally filtered and not secreted
Wastes are in low concentration in the blood
General strategy: filter almost everything into the tubule then reabsorb only the wanted substances. - Reabsorption of Nutrients
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Glucose, amino acids, vitamins, small proteins
Actively transported by carrier proteins or by endocytosis
Reabsorption nearly completed in the proximal tubule - Glucose Transport
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Saturable
Tmax is approximately 320 mg/min
Threshold is approx 180-220 mg/min
Coupled to Na+ reabsorption
Located only in proximal tubule - Glucose Filtered Load
- Filtered load (mg/min) = serum [ ] (mg/ml) X GFR (ml/min)
- Estimating GFR
- Plasma Clearance = Vol urine X [ ] urine
- Hormonal Regulation of UO
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Aldosterone
Antidiuretic Hormone
Angiotensin II
Atrial Natriuretic Peptide - Assessment of Kidney Function
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Pain:
irritative symptoms: UTI
CVA tenderness: pyelonephritis
renal colic: nephrolithiasis
Labs:
Urine: dipstick, urinalysis, C&S, 24 hour
Serum: BUN (10-20 mg/dl), creatinine (0.5-1.5 mg/dl) - Urinalysis
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pH (acidic)
protein (neg)
glucose (neg)
ketones (neg)
RBC < 5 cells per HPF
nitrites (neg)
leukocyte esterase (neg)
leukocytes < 5 cells per HPF
casts (neg) - Differential Dx of Hematuria
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Cystitis
Neoplasm
Stones
Glomerulonephritis (RBC casts) - Differential Dx of Proteinuria
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>150 mg/24h is significant
Functional proteinuria
Idiopathic and intermittent
orthostatic
glomerulonephritis
nephrosis: > 3.5 g/24h - Serum BUN and Creatinine
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Expect increase in Cr of 1 to 1.5 mg/dl per day in acute renal failure
Ratio of BUN to Cr may help predict prerenal hypovolemia if >20:1
Follow Cr in chronic renal failure as an indicator of GFR - Renal Disorders
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Obstructive
Infective (UTI, pyelonephritis)
Inflammatory (glomerulonephritis)
Chronic Renal Failure
Acute Renal Failure - Congenital Disorders
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Horseshoe kidney
Supernumerary kidney
Renal agenesis
Polycystic Kidney Disease - Obstructive Disorders
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Benign Prostatic Hyperplasia
Prostate Cancer
Bladder Tumors
Nephrolithiasis
Plugged Urinary Catheter - Urinary Tract Infection (UTI)
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Etiology: ascending infection, E. coli
Risks: female, urine stasis, high pH
Manifestations
Lower UTI: irritative symptoms
urine + for nitrites and leukocyte esterase
cloudy, foul smelling urine
Upper (pyelonephritis): CVA tenderness,
WBC casts, fever, nausea and vomiting
Treatment: antibiotics - Glomerulonephritis
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Etiology: Immune mediated damage to basement membrane
post-streptococcal, autoimmune
Risks: genetics, strep pharyngitis
Manifestations:
decreased GFR
leaky basement membrane
Treatment: steroids, chemo, supportive - “nephrotic”
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leaky basement membrane
hematuria
proteinuria - “nephritic”
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clogged tubules
decreased GFR
- oliguria
- edema
- hypertension
- azotemia - pyelonephritis
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cause: infection
s/s: fever cva tenderness
prognosis is good
treatment is antibiotics - Nephrotic Syndrome
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Ongoing Leaky Basement Membrane
proteinuria > 3.5 g in 24 hours
hypoalbuminemia
generalized edema
hyperlipidemia
Usually self-limiting - Chronic Renal Failure
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Who is at risk?
glomerulonephritis
diabetic nephropathy
pyelonephritis
polycystic kidney disease
nephrotoxic exposure
obstructive nephropathy - 75% nephron loss
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Decreased renal reserve
no signs or symptoms
BUN, creatinine normal
may not be diagnosed - 75% to 90% loss
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Renal Insufficiency
polyuria, nocturia
slight increase in BUN,creatinine
may be diet controlled - >90% nephron loss
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End-stage failure
uremia - Management of CRF
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Restrict: fluids, Na+, K+, PO4
Low protein diet
Phosphate binding antacids
Vitamin D supplementation
Dialysis
Renal Transplant - Acute Renal Failure (ARF)
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Sudden severe decrease in renal function
Prerenal
Intrarenal
Postrenal
Manifestations: Rapidly progressing uremia (50% mortality) - Causes of Prerenal ARF
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Inadequate Bloodflow to Kidney
shock
trauma
sepsis
hemorrhage
dehydration - Causes of Intrarenal &Postrenal
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Intrarenal: nephrotoxins
Postrenal: obstruction
BPH
stones - Differential Dx of ARF
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ATN (intrarenal, postrenal, prerenal)
lower urine osmolality (<350 mOsm)
urine sodium > 40 mEq/L
fractional sodium excretion >1.5%
tubular cell casts, protein in urine - Management of ARF
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PREVENTION:
assess for adequate renal perfusion
avoid nephrotoxins (some antibiotics)
early treatment of obstruction
TREATMENT:
acute dialysis
fluid management - URINE FORMATION
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SECRETION
TRANSPORT OF H+, NH4+, CREATININE, DRUGS, TOXINS, K+ , ORGANIC SUBSTRATES FROM TUBULAR EPITHELIAL CELLS INTO NEPHRON TUBES
i.e. from BODY towards URINE - FACTORS AFFECTING URINE FORMATION
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GLOMERULAR FILTRATION RATE
Hydrostatic pressure in glomerular capillaries (favors filtration) (~50 mmHg)
Hydrostatic pressure in BowmanÂ’s capsule (opposes filtration) (~15 mmHg)
Net Hydrostatic Pressure ~35 mmHg
Colloid osmotic pressure in glomerular capillaries (opposes filtration) (~25 mmHg)
Colloid osmotic pressure in capsule is negligable unless damage has occurred - CHANGE OF BLOOD PRESSURE THUS AFFECTS GFR
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AUTOREGULATION OF BLOOD FLOW TO KIDNEY (JG CELLS)
HORMONAL REGULATION : RENIN AND ANGIOTENSIN II, LATER ADH AND ALDOSTERONE
SYMPATHETIC NERVOUS SYSTEM PROMOTES GENERALIZED VASOCONSTRICTION (EXCEPT TO HEART, BRAIN, MUSCLES) - ABNORMAL CONSTITUENTS OF URINE
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GLUCOSE
Glycosuria
if active transport mechanisms for tubular reabsorption are exceeded, glucose is found in urine.
only occurs if carbohydrate intake is excessive that normal mechanisms canÂ’t clear it, or in pathologic condritions such as diabetes mellitus. -
Albumin
in urine -
Albumin
Albuminuria
most abundant blood protein, affects osmotic pressure of blood
should not pass through glomerular filtration membrane, but excessive exertion, pregnancy, overabundant protein intake may change permeability (physiologyical albuminuria).
Pathological: kidney trauma, heavy metal ingestion, bacterial toxins, glomerulonephritis, hypertension. - Ketone Bodies in urine
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intermediate products of fat metabolism
expected during starvation
pathological: diabetes mellitus if also find glycosuria
may cause acidosis - Red Blood Cells = Hematuria
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too large to pass through glomerular pores normally = pathology
kidney stones causing irritation and frank bleeding, physical trauma to urinary organs
may also be accidental contamination of urine by menstrual flow - Hemoglobin = hemoglobinuria
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result of fragmentation of red blood cells (hemolysis), liberating hemoglobin into plasma, which then appears in kidney filtrate.
pathological: hemolytic anemia, transfusion reaction, burns, renal disease - Bile pigments = bilirubinuria
- liver pathology like cirrhosis or hepatitis
- White blood cells = pyuria
- inflammatory process in urinary tract
- Casts = hardened cell fragments
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white blood cell casts, red blood cell casts (different forms of nephritis)
fatty casts (severe renal damage) - DISEASES AFFECTING URINE FORMATION
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Diabetes Mellitus
Diabetes Insipidus
Pathological conditions causing abnormal constituents in urine mentioned on previous slides. - Myenteric Plexus
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GI tract activity increases when stimulated
Tonic contraction of the intestinal wall inc.
Rhythmic contractions inc. in intensity
Rhythmic contractions inc. in rate
Velocity of conduction of excitatory waves along instestinal wall inc.
Excitatory fibers are cholinergic; inhibitory are purine-based NT such as ATP - Small Intestine
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2-4 hours to traverse
Segmental contractions to mix
Peristaltic waves to move forward - Large Intestine
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Slow progression at 5-10 cm per hour
Segmental contractions produce haustra
1-3 mass movements per day - Parietal Cells
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HCL
Intrinsic Factor - Chief Cells
- Pepsinogen
- Surface epithelia and mucous cells
- HCO3- and mucus
- Secretions from Pancreas
- HCO3-, Proteases, Lipases, Amylases
- Secretion from Gallbladder
- Bile acids, pigment, phospholipid
- Secretions from intestinal epithelia
- Brush border enzymes
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Brush Border Enzymes
lactase - lactose glucose, galactose
- brush border enzyme sucrase
- sucrose fructose, glucose
- brush border dextrinase
- cleaves amylose branch points
- brush border glucoamylase
- maltose glucoses
- Digestion and Absorption of Proteins
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Pepsin: 15% of peptide bonds broken
Pancreatic proteases
Trypsin
Chymotrypsin
Carboxypeptidases
Brush Border
Peptidases cleave into 1 to 4 aa chains - Digestion and Absorption of Fat
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Bile salts are amphipathic molecules that break up large fat globs into droplet
Lipase are water soluble - only work at surface of droplet
Triglycerides --------> FFA and glycerol
Bile forms micelles with FFA to keep soluble.
FFA are lipid soluble so absorb directly - Reabsorption of Bile
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Bile is reabsorbed at terminal ileum
Passive diffusion and active transport
Transported to liver via portal blood
ALL reabsorbed bile is taken up on first pass by liver
Entire bile pool circulates 2 to 5 times per meal. 5-10% lost per day in stool - GI Disorders
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Rank 3rd in total economic burden
60-70 million Americans have digestive disease
Many could be prevented or minimized by proper nutrition and changes in health practices - Dysphagia – difficulty in swallowing
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1. Neuromuscular: pharynx – problem in delivery of bolus of food or fluid due to neuromuscular incoordination
2. Peristaltic activity is altered: Stricture or tumor: Progressive solid food dysphagia
Achalasia: esophageal motility disorder, loss of peristalsis in lower 2/3 plus impaired LES relaxation – food feels “stuck”
3. Problems with bolus entry into stomach – esophageal tumors (scleroderma), obstructions at LES
Mallory-Weiss syndrome: mucosal tears at distal esophagus, bleeding, pain – often caused by excessive vomiting
Odynophasia – pain in swallowing - Esophageal Diverticulum
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Outpouching of the esophageal wall caused by weakness of the muscularis layer
Tends to retain food „³ leads to reports of gurgling, belching, coughing, and foul-smelling breath.
Trapped food causes esophagitis and ulcerations
Condition often progressive and may require surgery to correct defect - Oropharyngeal
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Nasal regurgitation
Airway obstruction with eating
Coughing when swallowing
Immediate regurgitation
Hoarse voice - Gastroesophageal Reflux Disease
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Backward movement of gastric contents into the esophagus „³ leads to heartburn
GERD „³most common dis in GI tract
Relaxation of LES is by vagus n.
Pain sometimes confused with angina
Persistent reflux leads to Barrett¡¦s esophagus ¡V squamous muscosa is replaced by columnar epithelium found in stomach or intestines.
Increases risk of esophageal cancer - Esophageal Cancer
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6% of all GI cancers
More common in over 50 – m/f = 2:1
Squamous cell - <50% - associated with dietary and environmental influences, ie., alcohol and tobacco use
Adenocarcinomas – often arise from Barrett’s esophagus - >50% and appears to be increasing
Located in distal esophagus and may invade the stomach
Endoscopy used to detect
Prognosis is poor b/c often metastasized before diagnosis - Disorders of the Stomach
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Gastric Mucosal Barrier - Stomach is protected by tight cellular junctions, a protective mucus layer, and prostaglandins that serve to protect by improving blood flow, inc. bicarb secretion and enhancing mucus production.
Gastric irritation caused by
Aspirin and NSAIDS – damage ep cells, dec mucus prod, and inhibit prostaglandin synth
and Heliobacter pylori – thrives in acid environment, disrupts mucosal barrier that protects stomach from digestive enzymes - Gastritis - Inflammation of gastric mucosa
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Acute – caused by local irritants like
bacterial endotoxins – like staph – abrupt and violent onset, vomiting
Caffeine, Alcohol, and Aspirin - Chronic Gastritis
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Chemical gastropathy
Reflux of alkaline duodenal contents, pancreatic secretions and bile into the stomach
Seen in pts. who have had gastroduodenostomy and gastrojejunostomy surgery - Peptic Ulcer Disease - PUD
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Since 1980’s – shift in thinking about cause
Most cases are H. pylori infection followed by NSAID and aspirin use
not so much due to genetic predisposition, stress or dietary indiscretions.
All duodenal ulcers and 70% of gastric ulcers have H.pylori
Cramplike pain is rhythmic and frequently occurs when stomach is empty – during the night
WhereÂ’s the pain?
Pain often alleviated by food and/or antacids - Dyspepsia
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Present with heartburn, indigestion, epigastric distress
Up to 2/3 will have no identifiable cause
One-half will have relief from placebo
Symptom profile does not differentiate between GERD, PUD, and non-ulcer dyspepsia (functional)
Physical exam is rarely helpful - Differential Diagnosis of gastro
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NSAID: suspect PUD and treat
Helicobacter pylori: urea breath test or biopsy during endoscopy
GERD: Trial of H2 antagonists therapy
Functional: may improve with agents that increase motility
Zollinger-Ellison syndrome: rare; caused by gastrinoma – gastrin secreting tumor; found mostly in pancreas – check gastrin level - PUD with H. pylori
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H. pylori is nearly always a factor in non-NSAID peptic ulcer disease
Conventional therapy with H2 blockers or H+ pump inhibitors has a 75-80% one-year recurrence rate
Treatment for H. pylori reduced recurrence rate to less than 5% - Cancer of the Stomach
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7th most frequent cause in US
22,400 Americans got it, 12,100 died
Major cause of cancer death worldwide
Factors include genetic predisposition, carcinogenic factors in diet (N-nitroso and benzyopyrene found in smoked and preserved foods), autoimmune gastritis, gastric adenomas or polyps.
Increased 4X since 1930s – why?
Often asymptomatic until late
Surgery is treatment of choice. - Irritable Bowel Syndrome
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Used to describe a functional GI disorder characterized by a variable combination of chronic and recurrent intestinal symptoms not explained by structural or biochemical abnormalities.
Hallmark is abdominal pain alleviated by defacation
Thought to be dysregulation of intestinal motor and sensory functions by CNS
Symptoms inc during stress
May have hormonal component as women notice exacerbations during premenstrual period and onset of disorder can occur during menarche. - Motility Diarrhea: IBS
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Irritable bowel syndrome is a chronic (>3months) functional disorder with no identifiable pathology
Fluctuations in stool frequency and consistency (no nocturnal diarrhea)
Perceived abd distention, bloating, pain
Often associated with anxiety or depression - IBS
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It is not IBS if fever, bloody stools, nocturnal diarrhea, or weight loss are present
Consider checking CBC, sed rate, albumin, and stool for occult blood to rule out inflammatory disease, consider lactose-free trial.
RX: restrict caffeine, gas producing food, high fiber. Rx depression - Inflammatory Bowel Disease
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Ulcerative Colitis
Involves only the colon and rectum (usually start of inflammation)
Begins most often b/t 20-25
Mucosal layer is affected
Hallmark is bloody diarrhea and lower abdominal cramps – 30-40 BM/day
Associated with increased cancer risk after 8-10 years of disease
Inflammation tends to be continuous
Mild chronic, chronic intermittent, and acute fulminating - Crohn Disease
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Recurrent granulomatous inflammation with skip lesions
Surface of bowel has “cobblestone” appearance
Mostly in submucosal layer - relatively sparing of smooth muscle layers
Intermittent bouts of fever, diarrhea, and RLQ pain, mass, and/or tenderness
Absorptive areas of intestine may be disrupted
Complications include fistula (tubelike) formation, perforation, abdominal abscess formation, intestinal obstruction
Can affect any portion of GI tract
30% are small bowel only
50% are small and large bowel
15-20% are large bowel only - Bowel Obstruction
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Presentation
Pain, distention, vomiting, obstipation
Evaluation
Flat and upright abdominal film
Small bowel: less urgent
intestinal tube, decompression
Large bowel: urgent, danger of cecal perf
immediate surgical consult - Diverticulosis
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Etiology:
Mucosal layer of colon herniates through muscularis layer
May be multiple diverticula
Common in western society 5-10% of pop older than 45, 80% older than 85
Almost non-existent in African and underdeveloped nations – Why?
Possibly diet (lack of fiber), dec physical activity, poor bowel habits, and aging - Diverticulitis
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Etiology:
Microperforation with peridiverticular inflammation
Presentation:
Elderly with LLQ pain, severe constipation, nausea, fever
Evaluation:
CBC, abd film, CT if peritoneal signs
Rx: NPO, antibiotics, IV fluids - Appendicitis
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Etiology:
Obstruction by fecalith (hard stool), twisting, inflammation
Presentation:
RLQ pain (classic, but may be anywhere), N&V, fever, diarrhea, RLQ tenderness
Evaluation: CBC, abdominal ultrasound
RX: immediate surgical consult - Diarrhea
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Affects 500 million children throughout the world and leading cause of death children under 4
About 220,000 american children hospitalized for gastroenteritis
Two-types
Large-volume
Small-volume - Chronic Diarrhea: Stool Studies
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Stool Osmolality: normal gap < 50
Laxative screen: Mg, PO4, SO4
Fecal leukocytes: Inflammatory disease
Ova and parasites: Giardia, cryptosporidium
Fecal Fat analysis: > 10 g/24 hrs indicates malabsorption
Fecal weight: > 1000 g is secretory - Malabsorption syndrome
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Syndrome implies a common constellation of symptoms arising from multiple causes.
Ex. Celiac sprue, CrohnÂ’s disease, and resection
Celiac sprue – rare chronic disease, mucosal lesion of small intestine and impaired nutrient absorption
Lose absorptive villi
Improves when gluten is removed from diet – maybe immunologic response - Colorectal Cancer
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2nd leading cause of death in US.
105,500 cases, 57,100 died
80% of pts are over 50
Inc with family history, CrohnÂ’s, UC and adenomatous polyps (most common neoplasm of intestine), perhaps diet
Aspirin may protect
May be asymptomatic for a long time
Bleeding often first symptom - Liver
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Liver is largest visceral organ – about 3 lbs.
Liver is surrounded by GlissonÂ’s capsule
Liver has dual blood supply
Hepatic artery brings 300 mls/min
Portal vein brings 1050 mls/min
Liver stores about 450 mls of blood – can be shifted back to circulation when needed
50-100,000 lobules in liver - Metabolic Functions of Liver
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CHO, Protein and Lipid Metabolism ¡V also builds CHO from proteins, converts sugars to fat for storage
CHO metabolism ¡V stores excess glucose as glycogen, converts galactase„³fructose„³glu,
Protein synthesis ¡V albumin, fibrinogen, clotting factors
Contains aminotransferases necessary for transamination
Oxidative deamination removes amino group from aa
NH3+ is generated (toxic to cells, especially neurons) so converted to urea in liver and excreted by the kidneys - Drug and Hormone Metabolism
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Metabolizes lipid-soluble substances that canÂ’t be excreted by kidneys
Phase 1 – chemical modification or inactivation of a drug
Phase 2 – conversion of lipid-soluble substances to water-soluble derivatives
Called biotransformation
Hormone inactivation – insulin and glucagon (proteolised or deaminated), T3 and T4 (deiodinated), steroid hormones (biotransformed) - Bile Production and Cholestasis
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Liver secretes about 600-1200 ml/day
Bile functions in the digestion and absorption of fats and fat-soluble vitamins from the intestine, helps excrete bilirubin, excess cholesterol and metabolic end-products that canÂ’t be eliminated in the urine
Approx 94% of bile salts are reabsorbed into portal circulation and recycled to liver
Bile salts travel this circuit about 18x before being excreted – called enterohepatic circulation - Cholestasis
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Decrease in bile flow
Results in bilirubin, cholesterol and bile acids accumulating in blood
May be caused by intrinsic liver disease – intrahepatic cholestasis;
Or by obstruction of large bile ducts – extrahepatic cholestasis
Bile accumulates in canaliculi and hepatocytes - Diff Dx: Jaundice - icterus
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Jaundice occurs with bilirubin level > 3 mg/dl (normal 0.2-1.2)
Increased RBC breakdown
Impaired liver uptake of bilirubin
Dec conjugation of bilirubin
Impaired excretion of bilirubin - Indirect bilirubin
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Unconjugated
Elevated with increased RBC breakdown or impaired liver uptake
Bound by albumin so no urine bilirubin - Direct bilirubin
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Conjugated- soluble in bile
Elevated with impaired excretion of bilirubin from liver
Water soluble, so is found in urine - Diff Dx: High Indirect Bilirubin
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Hemolytic process, hematoma
GilbertÂ’s syndrome: genetic impairment of bilirubin uptake by liver -benign
Crigler-Najjar syndrome: genetic deficiency of enzyme for conjugation
Liver bypass: portocaval shunt, cirrhotic shunt - Diff Dx: High Direct Bilirubin
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Hepatocellular injury:
hepatitis
drugs
hemochromatosis
Alpha-1 antitrypsin deficiency
Cholestasis:
stones, tumors, strictures
cholangitis - Acute Hepatitis
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Etiology: acute liver inflammation and cellular injury: viral, toxic
Three phases: prodromal or preicterus period, icterus, and convolescent period
Presentation: jaundice, anorexia, fatigue, diffuse abd discomfort, dark urine
Evaluation: History of viral or toxin exposure, AST, ALT, Alk phos, bilirubin, serology for viral hepatitis - Hepatitis A
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Formerly called infectious hepatitis
Caused by small, unenveloped RNA containing HAV
Brief incubation-15-45 days; usually transmitted by fecal-oral route.
Virus replicates in liver, excreted in bile, and sheds in stool (stopped by IgM inc)
Often occurs in epidemics
Drinking contaminated milk or water, or eating shellfish from infected waters
Children are often asymptomatic so help spread
Hep A vaccines are available - Hepatitis B
-
CDC estimates 200-300,000 new cases each year and 1.25 million chronic carriers
Endemic in regions of Africa and SE Asia
Caused by HBV – double stranded DNA v.
Complete virion, called Dane particle, has outer envelope and inner core with HBV
Longer incubation, more serious, transmitted through infected blood or serum. Antigen can be found in most secretions so can spread by oral or sexual contact.
Three antigens associated with virus
Hep B vaccine recommended for all children and pregnant women routinely tested - Hepatitis C
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Single stranded RNA v
At least 6 genotypes and multiple subtypes
How does this affect pathogenicity, immune mechanisms, and antiviral medications?
Most common cause of chronic hepatitis, cirrhosis, and hepatocellular cancer
Contaminated blood transfusions use to be most common route – now 1:103,000
Injecting drug use now highest risk factor, along with tattooing, acupuncture, body piercing
Incubation 15-150 days (ave. 50)
Children often asymptomatic, jaundice uncommon
Persistent v. that leads to chronic diseases - Hepatitis D
-
Hepatitis Delta Virus - defective RNA virus
Two forms
Coinfection with acute Hep B
Super-infection which Hep D is imposed on chronic Hep B
HDV can inc severity of HBV
Transmission similar to HBV
No direct treatment for Hep D but since it is tied to Hep B – prevent and treat Hep B - Acute Toxic Hepatitis
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Etiology: exposure to hepatotoxin or its metabolite
Evaluation: No definitive tests:
history of exposure is important
negative viral serology screen
improvement after discontinuing drug
if alcohol is the toxin, AST > ALT, 2:1 - Chronic Alcoholic Liver Disease
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Etiology: chronic, heavy ETOH exposure
Only 15-20% of alcoholics develop liver disease
Men > 4-6 drinks/day, Women > 3-4/day
Pathogenesis: unknown
Presentation:
fatty liver – steatosis; becomes enlarged
Hepatitis – common in “spree” drinkers
cirrhosis - Alcoholic-induced Liver Disease
-
Causes 200,000 deaths annually
5th leading cause
Estimated 10 million alcoholics in US but only 10-15% get cirrhosis
What does this suggest?
Death associated with liver failure, bleeding esophageal varices, and kidney failure - Cirrhosis of the Liver
-
Fibrotic liver – early stages called micronodular or Laennec cirrhosis
loss of hepatocellular functions
obstruction to bloodflow from the gut
Etiology
Chronic alcohol use (most common)
Biliary (obstruction in bile drainage)
Postnecrotic (viral, toxic hepatitis)
Cardiac (right heart failure, liver congestion) - Functions of the Liver
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Nutrient metabolism (glucose, protein, fat, fat soluble vitamins)
Production of serum proteins and enzymes (albumin, clotting factors etc.)
Detoxification of hormones, drugs
Bile synthesis (conjugation of bilirubin)
Urea synthesis - Manifestations of Liver Dysfunction
-
Inadequate bile synthesis
increased bilirubin level
jaundice
Inadequate urea synthesis
increased blood ammonia level (NH3)
hepatic encephalopathy
Release of marker enzymes into blood
AST (SGOT)
ALT (SGPT) - Occult GI Bleeding
-
Detected by FOBT: worry colorectal CA
Indicated for iron deficiency anemia in males or postmenopausal females
Unless S&S suggest Upper GI etiology (heartburn, dyspepsia PUD) start with colonoscopy (or barium enema)
If no source, follow with endoscopy - Acute Abdominal Pain
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Tension: spasm, associated with intense peristalsis (irritant, infection, obstruction)
Ischemia: intense constant pain (bowel strangulation, volvulus adhesion)
Inflammation: first localized to serosa covering inflamed part then extends to abdominal wall causing reflex muscle spasms (rigidity, involuntary guarding - Localization of Abdominal Pain
-
Stomach, duodenum: mid epigastric
Small bowel: periumbilical
Colon: low abdomen, midline
Rectum: sacrum and perineum
Gallbladder: mid epigastric radiates to RUQ or right scapula
Pancreas: mid epigastric radiate to back
Appendix: RLQ, but variable - Cholecystitis
-
Etiology:
95% associated with stone in cystic duct
Presentation:
Often obese female, fever, RUQ pain with scapular or epigastric pain, colicky, N&V
Evaluation:
CBC, RUQ ultrasound, HIDA scan
RX: Prompt cholecystectomy - Acute Pancreatitis
-
Etiology: unknown
Associated with ETOH, biliary disease
Presentation:
Severe epigastric and back pain
Evaluation:
CBC, glucose, calcium, electrolytes, amylase, lipase (renal studies)
Severity index - pancreatitis scale initially
-
Initially
Age over 55
WBC > 16,000
Blood glucose > 200
Base deficit > 4
Serum LDH >350
AST > 250 - pancreatitis scale first 48 hours
-
During first 48 hours
HCT drop of >10%
BUN rise >5 mg/dl
PaO2 < 60
Calcium < 8 mg/dl
Fluid sequestration of > 6 liters - Diff Dx: Steatorrhea
-
Pancreatic steatorrhea:
> 90% of exocrine function lost
Bile salt deficiency:
decreased ileal reabsorption (Crohn)
blocked secretion (cholestasis)
Bacterial overgrowth syndromes:
stasis of small bowel contents
Mucosal defects: Celiac disease (sprue) - esophagitis
-
reflux (GERD) - pain after meals
- “heartburn” - gastritis
-
ASA, ETOH - epigastric pain
H. pylori - Crohn's regional enteritis
-
? Etiology - diarrhea with
blood and mucus - ulcerative colitis
- ? Etiology - bloody diarrhea
- diverticulits
-
low fiber diet low abdominal
pain, fever - peritonitis
-
perforation - severe pain, ileus
bowel ischemia - guarding, rigid - pancreatitis
-
biliary disease - pain to back, shock
ETOH - high lipase, amylase - hepatitis
-
viral, acute ETOH - jaundice, big liver
- high AST, ALT
- flu-like symptoms