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viral infections of CNS

Terms

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HSV-1
encephalitis (MOST COMMON nonepidemic fatal encephalitis in U.S.)
Rabies
enters CNS RETROGRADE movment within neuron; causes FATAL ENCEPHALOMYELITIS; bites or breathing in bat urine; infected salive enters mm near nerves, birus multiplies and travels via azons to CNS, prelictes in neurons of gray matter and forms CYTOPLASMIC INCLUSION BODIES (NEGRI BODIES)
FATAL ENCEPHALOMYELITIS
RABIES
California Encephalitis group (Lacross Virus)
Bunyavirus #1 ARBOVIRUS NONEPIDIEIC ENCEPHALITS
Viruses cause what type of menigitis
aseptic menigitis
Postinfectious encephalamyelitis
from meales, mumps, and LAV vaccines will see inflammation and DEMYELINATION; NO TX CAN BE FATAL
St. Louis Encephalitis
#1 CAUSE OF EPIDEMIC ENCEPHALITS IN US in US attacks elderly
HSV-2
herpes virus causing menigitis
Enteroviruses
LEADING CAUSE OF ASEPTIC MENINGITIS (echovirs 6, 9, 11 and cosackievirus A9, B2, B4)
Arboviruses
obligatory cycle of multiplication occures in arthropod berfore transmission to next vertebrate host
Polio
infects the motor neurons of the anterior horn of the spinal cord and brain stem
Colorado tic Fever Virus
hundreds of cases annually-meningitis and encephalits
sx of polio
flacid paralysis (LMN lesion), paralysis of resp mm= death
HSV
infects cells in termporal lobes...reactivation of virus from trigeminal ganglia (NEURON TO NEURON TRANSMISSION
THREE PAHSES OF RABIES
prodormal (nonspeicific), excitation (anxiety, hydrophobia), paralytic (flaccid paralysis, stupor coma)
examples of arboviruses
togavirus, flavivirus, EEE, WEE, VEE (serious encephalitis), Bunyavirus, Reovirus
West Nile virs
mild general illness with fever-elderly get severe CNS dz
Mumps
seen in males, resp rout, rare encephalits but MOST COMMON CASUE OF ASEPTIC MENIGITIS IN NON IMMUNIZED POPULAITONS; post infectious encephalits can occure due to demyelination
Gillain-Barre Syndrome
inflammatory, demylinating respitory and GI illness 1 to 4 weeks after infection with asceding motor weakness
# 1 cause of paralytic diseas in US
Gillain-Barre Syndrome!!!

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