Flipinoff
Terms
undefined, object
copy deck
-
contraindicated if
sulfonamide allergy - Celebrex
-
Only 1 in 5 people who develop a serious upper
GI adverse event on NSAID therapy is - symptomatic
- Risk of gi bleed with NSAIDS increases with concurrent oral
- corticosteroids, anticoagulants
-
__ can cause fluid retention and peripheral
edema, particularly __ - NSAIDS, indomethacin
- Potentially fatal hypersensitivity syndrome
- Clinoril
-
Anaphylactoid reactions
are typically in asthmatic patients and more common in patients that are -
hypersensitive
to aspirin - Reduce dose of NSAIDS in patients with
-
renal or liver function
impairment; also the elderly -
NSAIDS not recommended in cases of advanced
kidney disease - Feldene -piroxicam, Mobic-meloxicam
-
metabolites may contribute
to kidney stones; keep hydrated - Clinoril-sulindac
-
Nausea, fatigue, lethargy, pruritis, jaundice, upper
right quadrant tenderness, flu-like symptoms are signs of - hepatotoxicity
-
Black Box Warning
For short term (up to 5 days) only
For moderate-severe pain
High risk of GI effects and Renal effects - Toradol
-
should be avoided within 2-3 hours of the
Aspirin dose - NSAIDS (non-specific)
- schedule of Hydrocodone products
- CIII
- All codeine, oxycodone and hydrocodone products are immediate release except
- OxyIR
- narcotic also available as injection and lozenge
- fentayl
- Dolophine
- methadone
-
narcotic; immediate release tablets and injection;
also available in solution and powder - methadone
-
Contraindications:
Acute or severe bronchial asthma
Upper airway obstruction
Significant respiratory depression
Premature infants
When delivery of a premature infant is anticipated - narcotic agonists
- narcotics with suicidal implications
- darvon, darvocet
- Oxycodone is category
- B
-
Do appear in breast milk, but effect may not be significant
Recommend to wait 4-6 hrs after use before breast feeding - narcotic agonists
-
Fentanyl
Black Box Warning: - Hypoventilation
- Duragesic Patch: Start at lowest dose⬦particularly elderly d/t
- muscle wasting and poor fat stores
- If use is required for more than 3 weeks, oral form can be dispensed at an approved maintenance program only
- methadone
- narcotic agonist potentially inappropriate in the elderly
- Darvon, Darvocet
- morphine precaution
- seizures
-
Most patients who receive opiates for medical
reasons do not develop - dependence
- Cigarette smoking may decrease pain relief from
- Darvon, Darvocet-propoxyphene
- two drugs which interact with Darvon, Darvocet-propoxyphene
- Tegretol and anticoags
- drug interaction with morphine
- anticoags
-
for spasticity from multiple
sclerosis, spinal cord injury, other spinal cord
diseases - Lioresal- baclofen
- for muscle spasticity
- Zanaflex - tizanidine
-
Because of similarities to tricyclic
antidepressants, consider all interactions
listed for tricyclic antidepressants - flexeril
-
hyperpyretic crisis, severe
convusions, and death have occurred in patients receiving tricyclic
antidepressants and - MAOIs
- __ may cause dry mouth (especially __)
- skeletal muscle relaxants, flexeril
-
Orally, start low and titrate up to therapuetic dose
* Abrupt withdrawal can result in hallucinations and seizures - baclofen
-
Intrathecal, screening phase with bolus dose before implant pump
* Abrupt discontinuation can result in high fever, altered
mental status, rebound spasticity, muscle rigidity - baclofen
- CAUTION in patients with psychotic features⬦can worsen
- baclofen
-
Like Baclofen, start at low, sub-therapeutic dose to determine
intolerance, then titrate up to therapeutic dose range - zanaflex
- Drowsiness, Dizzyness, Somnolence, Dry Mouth
- zanaflex
- Hypotension... caution with other alpha-adrenergic agonists (ie: Clonidine)
- zanaflex
-
Possible idiosyncratic Hypersensitivity
- Weakness, Disorientation, Confusion, Agitation - soma
- Skeletal muscle relaxants available injection as well as oral
- Robaxin and Norflex
-
Structurally related to tricyclic antidepressants⬦so higher incidence of drug
interactions on anticholinergic effects - flexeril
-
Known practically as the least sedating muscle relaxant
- Caution in hepatic impairment - skelaxin
- for cluster headache
-
Imitrex-sumatriptan
injection only -
Class of:
Maxalt
Zomig
Frova
Relpax
Amerge
Axert - Serotonin 5-HT1 Receptor Agonists
- May discolor urine brown, black, or green
- robaxin
- category for flexeril
- B
- Insomnia (specific agents)
- Restoril, Halcion, Dalmane
- Klonopin, Valium, Tranxene, Ativan (IV)
- seizures
-
Librium, Klonopin, Tranxene, Valium,
Dalmane; long or short? - long
- Ativan, Xanax, Restoril, Halcion; long or short
- short