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Drug Class - Antituberculars

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Five antituberculars?
ethambutol
isoniazid
pyrazinamide
rifampin
rifapentine
What are general uses for antituberculars?
used in treatment and prevention of tuberculosis
What are combinations of antituberculars used for?
treatment of active disease TB to rapidly decrease the infectious state and delay or prevent the emergence of resistant strains.
In selected situations, intermittent (twice weekly) regimens may be employed.
Which aminoglycoside (p35) is also used as an antitubercular?
streptomycin
Which antitubercular is used in the prevention of meningococcal meningitis and Haemophilus influenzae type b disease?
rifampin
Antituberculars kill (tuberculocidal) or inhibit the growth of (tuberculostatic) ________ responsible for causing tuberculosis.
mycobacteria
Combination therapy with two or more agents is required, unless used as ______(isoniazid alone).
prophylaxis
Hypersensitivity and severe ____ disease is a contraindication.
liver
Use antituberculars cautiously in patients with a history of ____ disease or in elderly or debilitated patients.
liver
Ethambutol requires _____ follow-up.
ophthalmologic
Safety in pregnancy and lactation not established, although selected agents have been used without adverse effects on the fetus. Compliance is required for optimal response.
okay
Which antitubercular inhibits the metabolism of phenytoin?
isoniazid
Which antitubercular significantly decreases saquinavir levels (combination should be avoided)
rifampin

Deck Info

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