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FA Pharm: Toxicology, Drug Rxns


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Toxicology: What is the antidote for acetaminophen toxicity/overdose
Toxicology: What is the antidote for salicylates toxicity/overdose
Alkanize urine/dialysis
Toxicology: What is the antidote for antichoinesterase toxicity/overdose
Atropine, pralidoxime
Toxicology: What is the antidote for antimuscarinic/anticholinergic agents toxicity/overdose
physostigimine salicylate
Toxicology: What is the antidote for Beta-blockers toxicity/overdose
Toxicology: What is the antidote fordigitalis toxicity/overdose
Stop digitalis, Normalize K+, lodpcaine, anti-digitialis Fab Fragments, Magnesium
Toxicology: What is the antidote for lead toxicity/overdose
CaEDTA, dimercaprol, succimer, penicillamine
Toxicology: What is the antidote for iron toxicity/overdose
Toxicology: What is the antidote for aresnic/mercury/gold toxicity/overdose
Dimercaprol (BAL), succimer
Toxicology: What is the antidote for copper, arsenic, gold toxicity/overdose
Toxicology: What is the antidote N-acetylcysteine used to treat?
Acetaminophen toxicity/overdose
Toxicology: What is the antidote for cyanide toxicity/overdose
nitrite, hydroxocobalamin, thiosoulfate
Toxicology: What is the antidote for methemoglobin toxicity/overdose
methylene blue
Toxicology: What is the antidote glucagon used to treat?
Beta-blocker toxicity/overdose
Toxicology: What is the antidote for carbon monoxide toxicity/overdose
100% oxygen, hyperbaric oxygen
Toxicology: What is the antidote atropine used to treat?
anticholinesterase toxicity/overdose
Toxicology: What is the antidote for methanol toxicity/overdose
Ethanol, dialusis, fomepizole
Toxicology: What is the antidote for opiods toxicity/overdose
Toxicology: What is the antidote for ethylene glycol toxicity/overdose
Ethanol, dialusis, fomepizole
Toxicology: What is the antidote for benzodiazepines toxicity/overdose
Toxicology: What is the antidote for (TCA) Tricyclic Antidepressants toxicity/overdose
Toxicology: What is the antidote for Heparin toxicity/overdose
Toxicology: What is the antidote Deferoxamine used to treat?
Iron toxicity/overdose
Toxicology: What is the antidote for warfarin toxicity/overdose
vitamin K, fresh frozen plasma
Toxicology: What is the antidote Naloxone/naltrexone used to treat?
opioid toxicity/overdose
Toxicology: What is the antidote for tPA/streptokinase toxicity/overdose
aminocaproic acid
Toxicology: What is the antidote Physostigmine salicylate used to treat?
Antimuscarinic/anticholinergic agents toxicity/overdose
Toxicology: What is the antidote Flumazenil used to treat?
Benzodiazepine toxicity/overdose
Toxicology: What is the antidote Protamine used to treat
Heparin toxicity/overdose
Toxicology: Children living in old houses might eat the paint chips which could cause ____
Lead Poisoning
Toxicology: Signs of Lead poisoning include:
Lead Lines on gingivae and epiphyses of Long bones, Encephalopathy and Erythrocyte Basophilic stipling, Abdominal colic and sideroblastic Anemia, Wrist and Foot Drop
Toxicology: 1st line of Treatment for Lead Poisoning include
Dimercaprol and EDTA
Toxicology: Weak acids, such as phenobarbitol, methotreaxate, aspirin, alkanize urine with ____ to increase clearance
Toxicology: Weak bases, such as amphetamines, acidify urine with NH4Cl to ____ clearance
Toxicology: AUTHOR
Lakshmi Swamy
Drug reactions: For each drug reaction, give the pharmacological agents responsible. The number of drugs you should list are given in parentheses. You could also quiz yourself in reverse by going down the list of drugs on the right.
Drug reactions: Pulmonary fibrosis (3)
bleomycin, amiodarone, busulfan
Drug reactions: Hepatitis (2)
isoniazid, halothane
Drug reactions: Focal to massive hepatic necrosis (4)
halothane, valproic acid, acetaminophen, amanita phalloides
Drug reactions: Anaphylaxis (1)
Drug reactions: SLE-like syndrome (4). [mnemonic: it's not HIPP to have lupus]
hydralazine, INH, procainamide, phenytoin
Drug reactions: Hemolysis in G6PD-deficient patients (8)
sulfonamides, INH, aspirin, ibuprofen, primaquine, nitrofurantoin, pyrimethamine, chloramphenicol
Drug reactions: Thrombotic complications (1 class)
OCPs (e.g. estrogens and progestins)
Drug reactions: Adrenocortical insufficiency (withdrawal of what class of drugs causes adrenocortical insufficiency?)
withdrawal of glucocorticoids causes hypothalamic-pituitary-axis supression
Drug reactions: Photosensitivity reactions (3) [mnemonic: SAT for a photo]
Sulfonamides, amiodarone, tetracycline
Drug reactions: Induce P-450 system (6)
barbiturates, phenytoin, carbamazepine, rifampin, griseofulvin, quinidine
Drug reactions: Inhibit P-450 system (6, including one fruit)
cimetidine, ketoconazole, grapefruit, erythromycin, INH, sulfonamides
Drug reactions: Tubulointerstitial nephritis (5)
sulfonamides, furosemide, methicillin, rifampin, NSAIDs (except aspirin)
Drug reactions: Hot flashes (1)
Drug reactions: Cutaneous flushing (4)
niacin, Ca++ channel blockers, adenosine, vancomycin
Drug reactions: Cardiac toxicity (2)
doxorubicin (adriamycin), daunorubicin
Drug reactions: Agranulocytosis (3, all start with letter C)
clozapine, carbamazepine, colchicine
Drug reactions: Stevens-Johnson syndrome (3)
ethosuximide, sulfonamides, lamotrigine
Drug reactions: Cinchonism (2)
quinidine, quinine
Drug reactions: Tendonitis, tendon rupture and cartilage damage (kids) (1)
Drug reactions: Disulfiram-like reaction (4)
metronidazole, certain cephalosporins, procarbazine, sulfonylureas
Drug reactions: Otoxicity and nephrotoxicity (3)
aminoglycosides, loop diuretics, cisplatin
Drug reactions: Drug-induced Parkinson's (4)
haloperidol, chlorpromazine, resperine, MPTP
Drug reactions: Torsades de pointes (two subclasses of antiarrhythmics)
Class III (sotalol), class IA (quinidine) antiarrhythmics
Drug reactions: Aplastic anemia (3)
chloramphenicol, benzene, NSAIDs
Drug reactions: Neuro/nephrotoxicity (1)
Drug reactions: Pseudomembranous colitis (2)
clindamycin, ampicillin
Drug reactions: Gynecomastia (5) [mnemonic: Some Drugs Create Awesome Knockers]
spironolactone, digitalis, cimetidine, chronic Alcohol use, estrogens, ketoconazole
Drug reactions: Atropine-like side effects (1)
Drug reactions: Cough (1)
ACE inhibitors (losartan --> no cough)
Drug reactions: Gingival hyperplasia (1)
Drug reactions: Diabetes insipidus (1)
Drug reactions: Tardive dyskinesia (1)
Drug reactions: Fanconi's syndrome (1)
Drug reactions: Gray baby syndrome (1)
Drug reactions: Extrapyramidal side effects (3)
chlorpromazine, thioridazine, haloperidol
Drug reactions: Osteoporosis (2)
corticosteroids, heparin
Alcohol toxicity: Ethylene glycol is converted to ------- ------ by alcohol dehydrogenase. This product can lead to acidosis and nephrotoxicity.
oxalic acid.
Alcohol toxicity: Alcohol dehyrogenase also converts methanol to formaldehyde and formic acid, which can cause severe ----- and damage to the -------.
acidosis. retina
Alcohol toxicity: Ethanol competes with ethylene glycol and methanol (if present) for alcohol dehydrogenase. ADH action on EtOH produces -------.
Alcohol toxicity: What symptoms does acetaldehyde cause?
nausea, vomiting, headache, hypotension
Alcohol toxicity: Acetaldehyde itself can be metabolized by acetaldehyde dehydrogenase to ----- -----.
acetic acid.
Alcohol toxicity: Acetaldehyde dehydrogenase is inhibited by what drug?
Herbal agents: Give the clinical uses for the following herbal agents.
Herbal agents: echinacea clinical use
common cold
Herbal agents: ephedra clinical use
as for ephedrine
Herbal agents: feverfew clinical use
Herbal agents: ginko clinical use
intermittent claudication
Herbal agents: kava clinical use
chronic anxiety
Herbal agents: milk thistle clinical use
viral hepatitis
Herbal agents: saw palmetto clinical use
benign prostatic hyperplasia
Herbal agents: St. John's wort clinical use
mild to moderate depression
Herbal agents: dehyroepiandrosterone clinical use
symptomatic improvement in females with SLE or AIDS
Herbal agents: Melatonin clinical use
jet lag, insomnia
Herbal agents: Give the toxicities for the following herbal agents.
Herbal agents: echinacea toxicity
GI distress, dizziness, and headache
Herbal agents: ephedra toxicity
CNS and cardiovascular stimulation; arrhythmias, stroke and seizures at high doses.
Herbal agents: feverfew toxicity
GI distress, mouth ulcers, antiplatelet actions
Herbal agents: ginko toxicity
GI distress, anxiety, insomnia, headache, and antiplatelet actions
Herbal agents: kava toxicity
GI distress, sedation, ataxia, hepatotoxicity, phototoxicity, dermatotoxicity
Herbal agents: milk thistle toxicity
loose stools
Herbal agents: saw palmetto toxicity
GI distress, decreased libido, hypertension
Herbal agents: St. John's wort toxicity
GI distress and phototoxicity; serotonin syndrome with SSRIs
Herbal agents: dehyroepiandrosterone toxicity
Androgenization (premenopausal women), estrogenic effects (postmenopausal), feminization (young men)
Herbal agents: Melatonin toxicity
Sedation, supresses midcycle LH, hypoprolactinemia
Drug category: For each drug name ending, give the general category of drug it indicates and an example of a drug in that category.
Drug category: -ane
inhalational general anesthetic. Halothane
Drug category: -azepam
benzodiazepine. Diazepam
Drug category: -azine
phenothiazine (neuroleptic, antiemetic). Chlorpromazine
Drug category: -azole
antifungal. Ketoconazole
Drug category: -barbital
barbiturate. Phenobarbital
Drug category: -caine
local anesthetic. Lidocaine
Drug category: -cillin
penicillin. Methicillin
Drug category: -cycline
antibiotic, protein synthesis inhibitor. Tetracycline
Drug category: -ipramine
tricyclic antidepressant. Imipramine
Drug category: -navir
protease inhibitor. Saquinavir
Drug category: -olol
beta antagonist. Propranolol
Drug category: -operidol
butyrophenone (neuroleptic). Haloperidol
Drug category: -oxin
cardiac glycoside (inotropic agent). Digoxin
Drug category: -phylline
methylxanthine. Theophylline
Drug category: -pril
ACE inhibitor. Captopril
Drug category: -terol
beta-2 agonist. Albuterol
Drug category: -tidine
H2 antagonist. Cimetidine
Drug category: -triptyline
tricyclic antidepressant. Amitriptyline
Drug category: -tropin
pituitary hormone. Somatotropin
Drug category: -zosin
alpha-1 antagonist. Prazosin

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