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pathology gi


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What is the most common disaccharide deficiency leading to malabsorption?
lactase => milk intolerance
Fundal gastritis (type A) is characterized by 4 A's, what are they?
Autoimmune disorder with Autoantibodies to parietal cells, pernicious Anemia, Achlorydia
Antral gastritis (Type B) is caused by:
a Bug, H. Pylori infection
Both forms of gastritis carry an increased risk of what?
Gastric carinoma
2 etiologic agents underlying gastric ulcers are:
H. pylori (70%) and NSAID's
Degeneration of what leads to gastric ulcers?
Gastric mucosal protection v. gastric acid
Does the pain of a gastric ulcer increase or decrease with meals?
Increases => weight loss
One etiologic agent underlies duodenal ulcers - what is it?
H. pylori (100%)
2 pathogenic mechanisms are thought to lead to development of duodenal ulcer - what are they?
Increased gastric acid secretion and decreased mucosal protection
What tends to hypertrophy with duodenal ulcers?
Bruenner's glands
The margins of a doudenal ulcer are:
clean and punched out
The 4 common complications of of duodenal ulcers are:
bleeding, penetration, perforation, and obstruction (not necessarily pre-cancerous)
Does the pain of a duodenal ulcer increase or decrease with meals?
Decreases => weight gain
How is H.pylori infection treated?
triple therapy (metronidazole, bismuth salicylate, amoxocillin or tetracycline) with or without proton pump inhibitor
Does smoking effect peptic ulcer development?
Yes, it is 2x as common in smokers
The possible etiology of Crohn's disease is:
The location and lesion type of Crohn's disease is:
Skip lesions in any portion of GI tract, usually terminal ileum, SI, and colon. Rectal sparing.
Gross Morphological features (6) of Crohn's disease are:
Transmural inflammation, cobblestone mucosa, creeping fat, bowel wall tickening (string sign on x-ray), linear ulcers, and fissure. (FAT OLD CRONE SKIPPING DOWN A COBBLESTONE ROAD)
The microscopic morphological features of Crohn's disease are:
non-caseating granulomas
The four major complications of Crohn's disease are:
Strictures, fistulas, perianal diease, malabsorption leading to nutritional depletion.
Two major extraintestinal manifestations associated with Chron's disease are:
migratory polyarthritis and erythema nodosum
The possible etiology of UC is:
Location and lesion type of UC is:
continuous lesions of colon with rectal involvement
The two gross morphological features of UC are:
mucosal inflammation, friable mucosal pseudopolyps with freely hanging mesentery.
The microscopic morphological features of UC are:
crypt abcesses, ulcers
3 severe complications of UC are:
severe stenosis, toxic megacolon, and colorectal carcinoma
Two major extraintestinal manifestations associated with UC are:
pyoderma gangrenosum, sclerosing cholangitis

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