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Human Diseases Pathogens to know


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Part of normal flora
Predisposing factors allow it to cause pneumonia
Causes 60-80% of all pneumonias.
Multiply in aveoli
Vaccine available Bacterial Pathogen
Streptococcus pneumoniae
Toxic shock-like syndrome,
Scarlet fever,Rheumatic fever,
Glomerulonephritis. group A b-hemolytic streptococci
Bacterial Pathogen
Streptococcus pyogenes
boils, pimples, impetigo
pneumonia, osteomyelitis, carditis, menigitis, arthritis, toxic shock syndrome
pathogenic strains produce more exoenzymes and toxins
Staphylococcus aureus
Diphtheria. Gram positive rods, stacked like Chinese characters
Loeffler’s medium allows growth without streptococcal competition
Diphtheria toxin gene carried by a temperate bacteriophage
Infects mucous membranes of the pharynx
Corynebacterium diphtheriae
Whooping cough (pertussis)
Gram negative, strictly aerobic coccobacillus
Highly infectious in children < 1 yr. old
Filamentous hemagglutinin antigen for adherence, exotoxin and endotoxin
Recurrent, violent cough up to 6 weeks
Bordatella pertussis
Tuberculosis (TB).
Caused 1/3 of deaths among healthy adults in the 19th century
Today >1 billion infected (20% of world population)
In U.S. common among homeless, malnourished, elderly or alcoholic poor
Mycobacterium tuberculosis
Meningitis. Meningococcemia. inflammation of the meninges (membranes lining the central nervous system)
can be caused by viral or bacterial infections, or can be aseptic
Neisseria meningitidis
Mycobacterium leprae
Viral Disease. ssRNA. Common Cold
Viral Disease. Influenza. ssRNA. influenza A (most important human pathogen)
a paramyxovirus
German Measles(Rubella) ssRNA.
a togavirus
Chicken Pox (varacella)and shingles (zoster)
herpes Virus

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