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Antianginal Agents


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Types of antianginal agents
-beta blockers
-calcium channel blockers
What causes angina pectoris?
When the supply of oxygen and nutrients in the blood is insufficient to meet the demands of the heart
Types of angina
-chronic stable angina
-unstable angina
-vasospastic angina
Therapeutic pbjectives of antianginal agents
-increase blood flow to
ischemic heart muscle
-decrease myocardial o2 demand
-prevent or delay the worst poss. outcome (MI)
Nitrates do what?
Cause vasodialation due to relaxation of smooth muscles
-Dialate coronary arteries
Nitroglycerin is used for...
...IV form is used for BR control in perioperative hypertension, tx of CHF, ischemic pain, and pulm. edema associated with MI
Two common Beta Blockers
Beta Blockers Mech. of Action
Decr. HR, resulting in decr. myocardial o2 demand and incr. o2 delivery to heart
Decr. contractility
Beta Blocker side effects
bradycardia, hpyotension, 2nd or 3rd degree heart block
Altered glucose and lipid metabolism
Name a Calcium Channel Blocker
Calcium Channel Blockers mech of action
cause peripheral arterial vasodilation
Result: decreased myocardial o2 demand
Calcium Channel Blocker therapeutic uses
-1st line agents for tx of angina, hypertension and supraventricular tachycardia
-Short term mgmt of a-fib and flutter
Patients taking beta blockers should...
...monitor pulse rate daily and report any rate lower than 60 bpm

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