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pathophysiology coagu. factors

Terms

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1
fibrinogen
2
prothrombin
3
tissue factor (TF) or tissue thromboplastin
4
calcium ions
5
proaccelerin
labile factor
platelet accelerator
6
# no longer used
substance now believed to be same as factor 5
7
serum prothrombin conversion accelerator (SPCA)
stable factor
8
antihemophilic factor (AHF)
9
plasma thromboplastin component (PTC)
Christmas factor
10
Stuart factor
Stuart-Prower factor
thrombokinase
11
plasma thromboplastin antecedent (PTA)
12
Hageman factor
glass factor
13
fibrin stabilizing factor (FSF)
erythrocytes
4-6 million/mm3
Duration:5-7days
life span:100-120days
transport O2 and CO2
leukocytes
WBC
spherical
nucleated cells
# 4000-11,000
granulocytes
1) neurophil
2) eosinophil
3) basophil
agranulocytes
1) lymphocyte
2) monovyte
neutrophil
# 3,000-7,000
D: 6-9days
LS: 6 hrs to a few days
phagocytize bacteria
eosinophil
# 100-400
D: 6-9days
LS: 8-12 days
kill parasitic worms
destroy Ag-Ab complexes
inactivate some infla. chemicals of allergy
basophil
# 20-50
D: 3-7 days
LS: ? (a few hrs to a few days)
release histamine & other mediators of infla.
contain heparin
lymphocyte
# 1,500-3,000
D: days to weeks
LS: hrs to years
mount immune response by direct cell attack or via antibodies
monocyte
# 100-700
D: 2-3 days
LS: months
phagocytosis
develop into macrophages in tissues
platelets
# 250,000-500,000
D: 4-5 days
LS: 5-10 days
seal small tears in blood vessels
instrumental in blood clotting

Deck Info

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