Wimmer Blood clotting I
Terms
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2 Major roles of platelets
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Form mechanical plugs, along with clot formation
Secrete chemicals that help regulate clotting process and vessel repair.
- 3 actions involved in platelet function during coagulation.
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-Adhesion to exposedsubendothelium components; collagen and vonWillebrand Factor
-Activation set off by adhesion, w/ ADP and TXA2 promoting aggregation
-Binding of fibrinogen to activated platelets
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3 phases of hemostasis
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Procoagulation
Anticoagulation
Fibrinolysis
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Fibrinogen -> fibrinopeptides + fibrin monomer
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FG- (A alpha)2 (B beta)2 (gamma)2
Fp- 2FpA + 2FpB
fibrin- (alpha beta gamma)2
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Hemophilia A and B
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A: no FVIII 80%
B: no FIX 20%
- How does asprin work as an anticoagulant?
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Irreversible suicide inhibition of platelet TXA2 synthesis
Inhibits TXA2 stimulation of platelet aggregation
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vWF, what does it do.
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released into blood: so factor VIII can bind and be stabilized
stay on cell surface: for platelet adhesion
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What are the 2 cofactors?
- FV and FVIII
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Why are Fp's negative?
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When cleaved, make a positive space on fibrin.
High amounts of asp and glu
PTM of tyr; sulfation of tyr's OH group