Wimmer Enzyme inhibition
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- HIV protease is what class of enzyme?
-
aspartyl
OR
acid protease
- Tell me about HIV protease's active site.
-
Two critical asp's.
A tetrahedral intermediate is formed during the rxn.
- Tell me about the drugs used against HIV protease.
-
Tight binding of tet. TS during rxn and -OH between the 2 asp's.
SO: hydroxyethylene group is used as an analog as tet. intermediate.