Wimmer Regulate enzyme activity
Terms
undefined, object
copy deck
-
Allosteric control of glycogen phosphorylase
-
Positive cooperativity in substrate Pi binding. (sigmoid)
Regulatory site communicating with catalytic site.
- Covalent modification glycogen phosphorylase
-
Reversible phosphorylation
Adding phosphoryl (-PO3) groups to ser side chans by phosphorylase kinase converts phos b to phos a, which is more active and stims glycogen breakdown.
Dephosphorylation by protein phosphatase converts phos a to p
-
Glycogen phosphorylase reaction
- Phosphorolysis of glycogen = G1P
- Inhibition and activation of glycogen phosphorylase
-
Feedback Inhibition: G6P and ATP
Allosteric Activation: AMP