neuro
Terms
-
ipsilateral vibration/proprioception loss w/ contralateral pain/temp loss
-
brown-sequard
cord hemisection
-
meningoencephalitis from swimming in fresh water lakes
-
naegri fowleri
- horner's is from lesions above?
-
T1
pacoast's, brown-sequard, syringomyelia
2nd order neuron starts at T1 spine, 3rd order starts in sup cervical ganglion at C2
- Nervous system phagocytes
-
microglia
Only nervous system cells that derive from mesoderm (like macrophages). all others from ectoderm
-
marker for astrocytes
-
GFAP
glial fibrillary acid protein
-
extrafusal fibers
-
alpha innvervation, force of contraction
- wernicke's aphasia
-
wordy but makes not sense
(think of the speech and confabulations of wernicke's encephalitis)
post/sensory area-->poor comprehension
- NTS
-
Sensory from 7, 9, 10
taste, barareceptors, gut distension
-
Nucleus ambiguus
-
motor of 9, 10, 11
swallowing and palate elevation
-
CNS myelin producers
- oligodendroglia
-
broca's aphasia
-
broken speech
ant/motor area-->can't talk but can understand well
-
dorsal column/medial lemniscus
- cross over 2 levels than ascend in ipsilateral fasculus cuneatus/gracilis. 1st synapse in nucleus cuneatus/gracilus in medulla. decusate and ascend in medial lemniscus. 2nd synapse in VPL
-
intrafusal fibers
-
bundled in sheath to form muscle spindle that is innervated by gamma and senses length of muscle
allow to pick up heavy suitcase w/out knowing weight ahead of time
-
limbic system
-
feeding, fighting, feeling, fucking
-
spinothalamic tract
-
paint/temp
cross right away. 1st synapse in spine on contralateral side. 2nd synapse in VPL
- which part of hypothalmus controls cooling
-
anterior
A/c
- PNS myelin producers
- schwann
-
schwann vs oligodenroglia
-
oligodenroglia--CNS, each myelinates 30 axons, bad in MS
schwann--PNS, each myelinates 1 axon, acoustic neuroma is a neoplasm of
-
Meisner's
Pacinian
Merkel's
-
light discriminatory touch in skin
Pressure, course touch, tension.looks like onion
tactile disk in fingertips, hair, hard palate. light, crude touch. cup shaped
-
utricle/sacule
semicircular canal
-
linear acceleration
angular acceleration
-
effects of direct basal ganglia pathway
-
from SNc, act on D1 receptors to activate putamen to activate GPi to inhibit thalmus that inhibits motor cortex
-->pro-kinetic and is decreased in parkinsons.
direct does direct (wanted) actions, indirect does indirect (unwanted) a
-
frontal lobe controls?
- executive function
-
level of illiac crests
-
L4/L5
site of LP
spinal cord ends at L1/L2
-
corticospinal tract
-
descending motor info
- golgi tendon
- senses force of contraction and sends inhibition back to alpha neurons to decrease the contraction.
-
dermatomes of:
back of skull
nipples
umbilicus
inguinal ligament
kneecaps
-
C2
T4 (teat pore)
T10 (belly butTEN)
L1 (L1 is IL)
L4 (down on L4s)
-
pudendal nerve block
- ischial spine
-
McBurney's point
-
2/3 from umbilicus to ASIS
-
dorsal motor nucleus
-
parasymph fibers to heart, lungs, upper GI
(vagus)
- function of lateral pterygoid
-
lower jaw
-
palatoglossus is inervated by?
-
vagus
all other "glossus" are by cn12
-
tensor veli palatini is innervated by?
-
V3
all other "palats" are by vagus
(tensor veli palatini was too tense for the vagus!)
other "tensor" by V3 too
-
arcuate fasiculus
-
connects broca's and wernickes
conduction aphasia: fluent aphasia w/ poor repetition, but good comprehension
-
Damage to amygdyla
-
kluver bucy: oral, sexual, disinhibited
-
damage to reticular activating system
- LOC
-
Bilat damage to mamilary bodies
- wernicke-korsakoff
-
damage to STN
-
controlateral hemibalismus
-
cerebellar damage:
hemisphere
vermis
-
limb ataxia, intention tremor
truncal ataxia, dysarthria
- right parietal lobe lesion
- left hemi-neglect
-
structures in cavernous sinus
-
CN III, IV, V1, V2, VI (everything through sup orbital fissure, plus V2)
carotid a.
-
senile plaques
-
extracellular, beta-amyloid
- neurofibrillary tangles
-
intracellular, silver stain/congo red, look like arrowheads
-
Genetic defect in alzheimer's
-
APOE4 on chrom 1, 14, 19
p-App on chrom 21
- diseases w/ tau protein
-
alzheimer's and Pick disease
Pick=frontotemporal dementia sim to zlazheimer. younger age of onset
-
inheritance of huntington's disease
-
autosomal dominant
atrophy of caudate
CAG repeat on chrom 4
- masked facies and cogwheel rigidity
- parkinson's
- friedrich's ataxia is what type of degenerative diease?
- spinocerebellar
-
werding-hoffmann disease
-
floppy baby, tongue fasiculations, dies at 7mo
degeneration of ant horns
- progressive mulitfocal leukoencephalopathy
-
JC virus, AIDS, a demyelinating disease
-
elevated CSF protein w/ normal cell count
-
Guillian Barre, MS
-
simple partial seizure
- no LOC, one part of brain
-
epidural hematoma
- lens shape, middle meningeal artery rupture, temporal bone fracture, lucid interval
-
subdural hematoma
- crescent shape, rupture of bridging veins, blunt trauma, elderly, shaken baby
- subarachnoid
- anneurysm rupture, worst HA of life, blood in CSF
-
Reflexes of:
biceps
triceps
knee
ankle
-
C5, C6
C7, C8
L4, L5
S1, S2
-
hemorrhage of mamillary bodies
-
wernicke korsakoff
-
argyll robertson pupil
-
respond to accomodation but not light
-
Bilat loss of pain and temp in upper extremities w/ preservation of touch
-
Syringomyelia
in pt's w/ arnold-chiari, most common C8-T1
-
Drug mechanism:
Benzodiazapine
Barbituate
-
Increase frequency of GABA-ergic Cl- channel opening
Increase duration of GABA-ergic Cl- channel opening
-
loss of tibial n.
-
can't stand on tip toes
the nerve plantar flexes and inverts
Tibial Inverts and Plantarflexes = TIP
-
loss of peroneal n.
-
foot drop (foot is inverted and plantar flexed)
-
pure motor stroke
-
post limb internal capsule
(lacunar)
-
pure sensory stroke
-
thalamus
(lacunar)
-
subacute sclerosing panencephalitis
-
rubeola (measles)
intranuclear inclusion in neurons/oligodendrocytes
-
cutaneous sensation of:
axillary
radial
musculocutaneous
median
ulnar
-
prox lat humerous
less prox lat humerous and dorsum of thumb
lat forearm
Index and middle fingers
ring and pinky fingers
-
cutaneous sensation of:
lat fem cutaneous of thigh
femoral
common peraneal
common peroneal w/ tibial
Tibial
-
lat thigh
ant thigh and ant leg
lat dorsum of foot
post leg
dorsum of foot
-
pronator teres syndrome
-
compression of median nerve passing through the muscle
-
Causes of Bell's palsy
-
AIDS, Lyme disease, Sarcoid, Tumors, Diabetes
ALexander BELL w/ an STD
- MLF connects?
-
nuc of CN3 wih nuc of CN6
-
neurotransmitter changes in:
alzheimers
Schizophrenia
Huntington's
Anxiety
-
decreased ACh
increased DA
decreased ACh, decreased GABA
increased NE, decreased GABA, decreased serotonin
- pramipexole, ropinirole
-
DA agonists
Bromocriptine too
-
entacapone, tolcapone
-
prevent DA breakdown (COMT inhibitors)
Selegiline (MAO-B inhibitor)
- Benzotriptine
-
Antimuscarinic used in Parkinson to improve tremor and rigidity
- parkinson's tx
-
BALSA
Bromocriptine, Amantadine, Levo/carbidopa, Selegiline, Antimuscarinic (Benzotriptine)
- flumazenil
-
GABA competetive inhibitor
-
toxicity of:
Halothane
Methoxyflurane
Enflurane
-
Hepatotoxic
nephrotoxic
proconvulsant
-
thiopental vs propofol
-
both IV induction agents
propofol w/ less post-anesthesia nausea
-
Ketamine SE
-
CV stimulant, bad dreams, increased cerebral blood flow.
-
most common drug used for endoscopy
-
IV midazolam
post-op respiratory depression, drop in BP, amnesia
- endrophonium is?
- a cholinesterase inhibitor
-
tx for malignant hyperthermia
(caused by used of succinylcholine and inhaled anesthetic together)
-
Dantrolene
prevents release of Ca2+ from sarcoplasmic reticulum
-
first line for:
tonic-clonic
Absence
status
pregnancy
-
phenytoin, carbamazepine, valproic acid
ethosuximide
Lorazepam
phenobarbital
-
when do DT's kick in after stopping EtOH
-
2-5 days after last drink
tx w/ benzos