cytokines
Terms
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- g-IFN
-
Stimulates macrophages. Creates histeocytes in granuloma formation.
- IL-1
- pro-inflammatory. CAUSES FEVER. secreted by macrophages.
- IL-10
-
Inhibits Th1
- IL-11
- stimulates megakaryocytes-->platelets
- IL-12
- Activates NK and Th1 cells. Secreted by macrophages (and B cells)
- IL-2
-
Activates T-cells
-
IL-3
- Growth and differentiation of bone marrow
- IL-4
- Growth of B-cells. IgE and IgG class switching.
- IL-5
-
Differentiation of B-cells. IgA class switching. activation of eosinophils.
- IL-6
- Stimulates production of acute phase reactants. Secreted by macrophages (and Th)
- IL-8
-
Neutrophil chemotactic factor
- secreted by macrophages?
- IL-1, IL-6, IL-12, TNF-a
-
TGF-B
- anti-inflamatory
- TNF-a
-
increase IL-2 receptor synth; increase b-cell proliferation; attract and activate neutrophils; stimulate dendritic migration to lymph node.