Physics of Anesthesia  exponential func., diffusion, osmolarity
Terms
copy deck
 rate of change determined by quantity
 exponential process
 examples of exponential processes

thermal dilution CO measure
replacement of N2 in lungs w/ O2
anesthetic removal from body  3 compartment distribution of a drug is reflected in a washout curve with...
 3 exponential processes, each reflected as a tangent off of the decay curve
 steep early portion of decay curve
 rapid elimination phase
 shallow tail of decay curve is a function of...
 metabolic processes
 cool liquid holds (more/less) gas
 more...because doesn't have energy to escape surface
 volume of gas dissolved in 1 volume of liquid at 1 atmosphere
 Bunsen solubility coefficient
 Ostwald and Bunsen solubility coefficients and partition coefficient all depend on...
 temperature
 volume of gas dissolved in 1 volume of liquid
 Ostwald solubility coefficient
 Ostwald solubility coefficient differs from Bunsen how?
 independent of pressure
 ratio of amt of substance in two phases of equal volume
 partition coefficient
 ED50 (effective dose in 50%) of anesthetic
 MAC (minimum alveolar conc.)
 potency of anesthetics is proportional to...
 solubility in oil
 at the end of one time constant, what percentage remains? two time constants? three?
 37%, 13.5%, 5%
 FA/FI

fraction alveolar concentration/
fraction inspired concentration  one Avogadro's number of particles of solute that cannot diffuse through a semipermeable membrane
 one osmole
 the pressure which will prevent osmosis of a solvent into a solution
 osmotic pressure
 1 GMW or 1GAW dissolved in 22.4L of water (0 degrees C) has osmotic pressure =
 1 atm
 1 GMW of a gas expands at STP to what volume?
 22.4 L
 37C 1mOsm/L has osmotic pressure
 19.3 mmHg

blood:gas partition coefficient 37C
enflurane  1.91

blood:gas partition coefficient 37C
halothane  2.3

blood:gas partition coefficient 37C
isoflurane  1.4

blood:gas partition coefficient 37C
methoxyflurane  12

blood:gas partition coefficient 37C
nitrous oxide  0.47

blood:gas partition coefficient 37C
sevoflurane  0.60

blood:gas partition coefficient 37C
desflurane  0.42