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N224 Pathophysiology - Exam 3 - MSU - Huether chapters 19,20


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Name the 6 TYPES of hematologic alterations. (According to the professor)
Erythrocyte fx
Myeloproliferative RBC disorders
Leukocyte Fx
Lymphoid Fx
Splenic Fx
Platelets and coagulation
Define Anemia
the reduction in total # of erythrocytes or the decrease in quantity or quality of hemoglobin
Name the 3 main causes of Anemia
altered production of e-cytes
blood loss
increased destruction of e-cytes
Normocytic, macrocytic and microcytic refer to what re: anemia?
the erythrocyte volume (size)
normochromic, hypochromic refer to what re: anemia?
the Hemoglobin content
What does pernicious mean (physiologically speaking)?
B12 defieciency
According to professor, what are the 3 types of anemia.
normocytic-normochromic (least common)
Describe the differences in manifestation between B12 deficiency and Folate deficiency
Folate deficiency manifests the same as B12 deficiency except for the neurological symptoms.
(weakness, paresthesias of feet and fingers, difficulty walking)
How fast do macrocytic-normochromic anemias develop?
Slowly, over 20-30 years.
What physiological activity does the B12 or folate deficiency directly affect, which in turn affects the e-cyte synthesis
RNA and DNA synthesis

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