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Renal Pathology


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alpha-5 chain of type IV collagen
Alport syndrome
Sensorineural hearing loss and ocular abnormalities
Alport syndrome
Splitting and lamellation of GBM
Alport syndrome
Normal renal function, normal LM and IF, microscopic hematuria
Thin basement membrane disease
Recurrent gross but asymptomatic hematuria following infection
Berger's IgA nephropathy
LM: mesangial proliferation, focal segmental endocapillary proliferation or sclerosis
IF: mesangial IgA
EM: mesangial granular deposits
Berger's IgA nephropathy
alpha-3 chain of type IV collagen
Goodpasture's syndrome
LM: focal segmental fibrinoid necrosis, cresentic proliferation
IF: linear staining with IgG, C3
Goodpasture's syndrome
Pauci-immune glomerulonephritis
Wegener's granulomatosis, Churg-Strauss, polyangiitis, ANCA-related)
Immune complex-mediated nephritis
Lupus nephritis, Henoch-Schonlein purpura, MPGN, IgA nephropathy, postinfectious GN
WBC casts in UA, flank pain, fever, dysuria
Acute pyelonephritis
Dysuria, frequency, urgency, without fever, bacteriuria and pyuria
Acute cystitis
Wire loops, hyaline thrombi, hematoxylin bodies
Lupus nephritis
Humps (subepithelial deposits)
Acute postinfectious GN
Tubuloreticular inclusions
Lupus nephritis
Wegener's granulomatosis
Churg-Strauss syndrome
Transmural arteritis and fibrinoid necrosis; no involvement of glomeruli
Polyarteritis nodosa
Systemic necrotizing vasculitis with small vessel involvement
Wegener's granulomatosis
Hepatitis B infection
Polyarteritis nodosa
Squamous carcinoma of the bladder
Mesangial IgA deposits
Henoch-Schonlein purpura
Segmental to diffuse cortical necrosis
Hemolytic uremic syndrome (HUS)
Kimmelstiel-Wilson nodules
Diabetic glomerulosclerosis
Epithelial foot process effacement
Minimal change disease/nil lesion
Subendothelial humps; tram-tracks
Membranoproliferative GN
Membranous GN: nephrotic or nephritic?
Membranoproliferative GN: nephrotic or nephritic?
Diffuse capillary and basement membrane thickening
Membranous GN
Most common cause of childhood nephrotic syndrome
Minimal change disease
Common cause of adult nephrotic syndrome
Membranous GN
von Hippel-Lindau and gene deletion in chromosome 3
Renal cell carcinoma
Most common renal malignancy of early childhood (ages 2-4)
Wilms' tumor
Most common tumor of urinary tract system
Transitional cell carcinoma
Thyroidization of kidney
Chronic pyelonephritis
WBC casts in urine
Acute pyelonephritis
Most common cause of acute renal failure
Acute tubular necrosis

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