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10. Lymphoma


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What are lymphomas?
Who diagnosis them?
-Diagnosed by pathologists.
What is the formal definition of lymphoma?
A heterogenous group of malignant disorders originating from immune cells; invade the BM secondarily.
What are the 2 classifications of lymphoma?
1. Hodgkin's lymphoma
2. Non-hodgkin's lymphoma (NHL)
What patients get Hodgkin's?
2 groups!
-from 15-35 yrs olds
-over 50s.
What symptoms must be present in order to diagnose Hodgkin's?
1. Nodal changes - in cells AND stroma - architecture in general
2. Clinical symptoms.
What is the major clinical symptom of hodgkin's?
Enlarged, non-painful, rubbery cervical lymph nodes.
What type of cell is seen in hodgkin's?
REED-STERNBERG CELLS - huge cells that really jump out.
Are Reed-sternberg cells alone enough to diagnose Hodgkin's?
No - can show up in viral infections like mono, too.
What is the med tech's role in diagnosing Hodgkin's?
Recognizing Reed-Sternberg cells on the bone marrow aspirate; distinguish it from Megakaryos, Osteoclasts, and Histiocytes.
What is the prognosis of younger patients with Hodgkin's?
Excellent - w/ chemo and radiation often go into remission.

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