Eicosanoid Pharmacology
Terms
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dexamethasone
hyrocortisone
prednisone
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gluccocorticoids
PLA2 blockers (RLS of eicosanoid synth)
tx: asthma, RA, inflammation
many s/e's
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Aspirin (ASA)
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COX inhibitor (NSAID)
irreversible
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Ibuprofen
Naproxen
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COX inhibitor (NSAID)
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Acetaminophen
Bonus: what is its antidote in case of overdose?
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COX inhibitor
poor anti-inflammatory
good anti-pyretic (via COX-3?)
OD antidote: N-acetyl cysteine
- Celecoxib
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COX-2 inhibitor
- Zileuton
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5-LOX inhibitor
tx asthma
low efficacy