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chpt 9


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3 similarites of Ig and TcR
2 differences
1. both in Ig domain superfamily members
2. both undergo gene rearrangement
3. both contain multigene families
main differences between TcR and BcR
distinct recognition and effector mechanisms
how many CDRs in each V chain of TcR?
3; because two V chains, total 6 CDRs
what do CDRs bind to?
how many multigene families encode the T cell receptor?
4; alpha, beta, delta, gamma
gene segments for alpha and gamma:

for beta and delta:

what is the MAIN DIFFERENCE between TCR and Ig genes?
only one or two Constant genes for TcR; no class switching, NO DIFFERENTIAL RNA PROCESSING
3 enzymes for gene rearrangement
Rag 1 and 2, dsbr
difference in gene rearrangement of TcR
additional alternative joining of D gene segment in B and delta cuz of RSS arrangement; more diversity in TCR than Antibodies.
4 additional molecules necessary for interaction of TcR with Ag:
CD3 complex
Adhesion Molecules - think of glue, adhesive strip
WHEN do adhesion molecules help TcR bind to Ag/MHC
after interaction of the aforesaid; enhanced display of these molecules when the cell is activated allows longer tango
allograft organ transplant
tissue transfer between organisms of same species but different genes
why do CTL's recognize allograft transplants, when they should only recognize SELF mhc???
Cross-reactivity of TCR; the CTL binds to the foreign peptide/foreign MHC with LOW AFFINITY, but yet it does bind.

remember there is a lot more MHC1 on cells than MHC2; this overcomes the weak interaction. by sheer force of #

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