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Gram (-) parasites


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Virulence of Chlamydia trachomatis:
lysosome resistance, prevents lysosome-phagosome fusion
Treatment of Chlamydia trachomatis:
doxycycline, erythromycin, and azithromycin
Diagnosis of Chlamydia trachomatis:
won't grow on artificial media--no Gram (-) diplococci, anti-chlamydia antibodies
Virulence for Rickettsia:
Grows in cytoplasm, endothelial blood vessel lining
Treatment for Rickettsia:
Doxycycline, Chloramphenicol
Diagnosis for Rickettsia rickettsi:
Chick yolk sac media, Weil-Felix Reaction, Anti-Rickettsia antibodies
Patient presents with rash on wrists, ankles, soles & palms, severe headache, and conjunctivitis. Reports recent hiking trip. suspect?
Rickettsia rickettsi--Rocky Mountain Spotted Fever
Causes Epidemic Louse-borne Typhus & Brill Zinsser Disease:
Rickettsia prowazekii
Treatment of Rickettsia prowazekii
Doxycycline, Chloramphenicol, eradicate lice
Causes Scrub Typhus:
Rickettsia tsutsugamushi
Causes Cat-scratch fever & Bacillary anglomatosis:
Bartonella henselae
Causes Trench Fever:
Bartonella quintana
Causes Q Fever (no rash)
Coxiella burnetii
Patient presents with a painless wart on scrotum & arthritis-like symptoms. suspect?
Treponema pallidum (Syphilis)
Diagnosis of Treponema pallidum:
Causes Yaws:
Treponema pertenue
Causes Lyme disease:
Borrelia burgdorferi
Diagnosis of Borrelia burgdorferi:
ELISA, Western immunoblotting
Causes Weil's Disease:
Leptospira interrogans

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