This site is 100% ad supported. Please add an exception to adblock for this site.

Ischemic Heart Disease Study Guide

Terms

undefined, object
copy deck
a fixed atherosclerotic plaque will lead to
a. chronic stable angina
b. unstable angina
c. variant angina
d. printzmetal's angina



a. chronic stable angina
unstable agina is also known as
a. stemi
b. nstemi

b. nstemi

a ruptured plaque with or without a thrombus that is non occlusive is
a. nstemi
b. stemi

nstemi
if you have an nstemi you should administer anitcoagulants and antiplatelet drugs ... which ones
thienopyridine or maybe glycoprotein IIb/IIIa inhibitors for anti platelet

and anticoagulants like heparin or lmw heparin

a stemi is caused by
a. ruptured vulnerable plaque with occlusive thrombus
b. non occlusive plaque
c. spasm


a. ruptured vuln. plaque with occlusvie thrombus
what drugs to give to a pt with a STEMI?
strong anti platelet therapy and maybe anti coagulant
beta blocker to reduce recurrent mi risk
ace inhibitor or ARB preventing adverse remodeling
long term aspirin therapy reducing mi recurrence

dont forget to treat underlying risk factors, you might need statins or something






what is variant angina caused by and whats another name for it?
printzmetals
spasm




what do u give to a pt with printzmetals angina
vasodilator
what type of vasodialator to give to a pt with variant agina?
vasodialator esp calcium channel blocker
whats the MOA of aspirin
ihibits cox-1 which prevents platlets from making thrmoboxane thus decreasing aggregation tendancy ... irreversible
what is the prototype drug of the thienopyridines and what are they used for?
anti platelet
clopidigrel
what is the mechanism of clopidigrel
block an adenosine receptor to prevent platelet activation
what is the prototype drug for glycoprotein IIB/IIIA inhibitor
abciximab
what does abciximab do
what kinda drug is it
inhibit platelet activation
glycoprotein IIb IIIa inhibitor
what is the mechanism of dipridamole
inhibits phosphodiesterase and therefore increases cAMP
anti-platelet
indirect thrombin inhibitors are
a. anti platelet
b. anti coagulants

a antiplatelet
what type of drug is heparin
anti coag
indirect thrombin inhibitor
what is the mechanism of thrombin
binds to anti thrombin III and causes a configuration change that results in more efficient inactivation of thrombin
if you want a longer lasting indirect thrombin inhibitor would you chose
lmw heparin or heparin
lmw heparin
what is the major adverse side effect of heparin
lmw heparin
thrombocytopenia for both and osteoporosis with long term use for lmw heparin
what are direct thrombin inhibitors used for? name some drugs
anti coag
hirudin, bivalrudin, argatroban
what is a drug that is an anti coagulant that is a vit k blocking agent
warfarin
what is the mechanism of warfarin
blocks vit k dependent production of clotting cascade proteins in the liver
does warfarin work immediately or does it take a few days
takes several days to work bc the factors that we do have have to be depleted
name two fibrinolytic drugs
streptokinase and tissue plasminogen activator
what is the difference in selectivity of streptokinase and tissue plasminogen activator
tpa is more selective for plasminogen bound to clot so less of a systemic effect
name some nitroglycerin drugs
what do they do
nitroglycerin, isosorbide, mononitrate

vasodialate by increasing NO in vascular endothelium leading to relaxation of vascular smooth muscle

dihyrdopyridines are used for what?
vasodialation
what are two prototype dihyrdropyridines?
nifedipine and amlodipine
what is the mechanism of nifedipine?
block calcium channels in vsm cells leading to vasodialation
what is the mechanism of amlodipine
block ca channels in vsm cells leading to vasodialation
what do dihydropyridines do to heart rate
increase heart rate in reflex manner
what does nifedipine do to heart rate
increases it
what does amlodipine do to heart rate
increases the heart rate in a reflex manner
what drugs are used to decrease myocardial demand?
beta blockers and non-dihydropyridine calcium channel blockers
what are two prototypical drugs of the beta blocker class
propranolol and metprolol
what is the mechanism of metoprolol
block beta receptor on myocardium leading to decreased heart rate (pacemaker cells) and decreased contractility of myocytes
what are two prototypical non-dihydropyridine calcium channel blockers
verapamil and dilitazem
would u use verapamil or ditiazem on a persone with lv dysfunction
no they have a very neg inotropic effect

Deck Info

39

swimaline

permalink