cardiology pharm
Terms
undefined, object
copy deck
- class III drugs work on what phase of the AP?
- 3
- Class three drugs affect what channels and what heart prob are they primarliy used for?
- k channel blockers, re entry arrythmias
- class I: what phase of ap what channels what heart probs do they work for?
- fast sodium channel blockers, phase 0, affect atrial and ventricular arrythmias
- class II: what does it block and what phase does it work on and what heart prob
- beta blockers phase 4 act agains atrial and ecessive catecholamine arrhythmias
- class 4 drugs: what ion channel do they work on what phase of ap what heart prob doe they work for
- calcium channel blockers and phase 4 of ap and work agains atrial and acute myocardial ischemia -induced arrhythmias
- what is a prototype class IA drug?
- quinidine
- what effects do class IA drugs have on ekg
- affect condution and ap duration. moderate depression. they also block k channels and prolong repolarization. th drugs cause increase and widenin in qrs intervals and increase the QT. thus there is a risk of torsades
- what drugs should you not use if you are worried about torsades de pointes?
- quinidine, a class IA drug
- something that dr. ku said would be tested on!! what is a major side effect of procainamide?
- systemic lupus like problem
- procainamide is what class of drug and what is its major side effect?
- systemic lupus like prob, class IA
- What is the prototype Class IB drug?
- lidocaine
- what is the ionic effect of class IB, or moa?
- block fast sodium channels in inactive state. little depression in condution of ap, minimal effect on sodium, modest decrease in ap duration. really affecting open k channels.
- from slide 24. a slide that dr. ku emphasized that we should memorize... Least cardiotoxic of all antiarrhythmics drug of choice for post-MI, heart surgery, and digoxin ??toxicity
- class IB
- which drug is not useful against atrial arrythmias... dr. ku said this would be testable
- class IB.
- which drug\'s plasma half life is about 10 mins but chemical half life is about 2 hours? ku said this was testable
- lidocain. class IB drug. slide 24 of jan 7 10 am lecture
- what are the adverse effects of class IB drugs?
- mostly cns related such as seizure tremor twitching headache and blurred vision. ku said this was testable jan 7 slide 24 10 am
- what drug that is a class IB like lidocain is actually orally effective?
- tocainide ... testable according to dr. ku. from slide 24 jan 7 10 am
- what class of drugs causes severe depression in conduction?
- class IC
- what is the prototype class IC drug and what effect does it have on ekg
- flecainide. prolonged qrs. they are a second or third line anti arrhythmatic... primary for chronic stable ventricular arrhythmias.
- what problems can flecainide precipitate and what class of drug is it ?
- class IC, affects fast sodium channels, phase 0 of ap, can lead to congestive heart failure.
- what anti arrhymia drug is pro-arrhythmic? what class of drug is it? name the prototype
- flecainide is the prototype class IC drug that eleminates one reentry but creates one somewhere elses.
- class II anti-arrhythmatic drug prototype? what is it indicated for
- supraventricular arrythmia, ventricular arrhythmia... affects phase 4 of AP. propranolol
- what channels do class II drugs work on?
- beta blocker
- what are the principal electrophysiological actions of class II drugs. name the prototype class II
- propranolol. inhibit synthetic modulation of SA node and decrease AV node transmission
- Class three drugs: what channel does it act on, what is a prototype
- block the delayed rectifier current (IK), amiodarone, dronaderone
- pts with asthma should stay away from which drugs?
- beta blockers
- which class III interacts badly with iodine
- amiodarone
- what problem is class III drug likely to cause?
- torsades because it makes the qt interval longer
- a patient is on amiodarone and notice an increased QT wave on ekg... why is this worrisome?
- bc class three drugs make the qt interval longer and are likely to cause torsades de pointes.
- if a pt is on a class III drug and has an elongated qt, would switching to a quinidine, a class IA eliminate worry of causing torsades de pointes?
- no. they both can cause it.
- true or false: amiodarone and quinidine can both cause torsades de pointes?
- true
- true or false? amiodarone, a class III drug, represents the only class of drugs that might cause torsades de pointes?
- false. class IA, like quinidine can also cause elongated qt and torsades
- why is donaderone a better class three than amiodarone?
- dronaderone does not have a prob with iodine.
- what class of drugs prolongs the ERP without effecting the conduction phase? (slide 31, jan 7, 10 am)
- class three drug
- jan 7 10 am slide 31. testable material according to scribe: what class III drug produces both class II and class III actions. what is it indicated for?
- sotalol. both class II beta blocker effect and class III, phase 3 of AP, for life threatening ventricular arrythmias
- what is dofetilide indicated for? slide 31 jan 7 10 am scribe said that this material was very testable
- indicated for atrial fib. and flutter.
- what class of drug is sotalol?
- class III
- what class of drug is dofetilide?
- class III
- what class of drug is ibutilide?
- class III
- what is ibutlide indicated for?
- atrial flutter and fib.
- what is a\"pure\" class III drug?
- ibutilide
- what channel do class IV drugs act on. what phase of AP do they act on?
- slow ca channel, phase 0 and phase 4
- what is a class I drug of the class IV drugs? hmm thats confusing.
- phenylalkylamines. class I cardiac calcium channel blocker -- verapamil
- what is a class II drug of the class IV drugs?
- diltiazem. benzothiazepines. cardiac calcium channel blocker
- what is a class III of the class IV drugs/
- dihydropyridines -- all the dipines are for vascular calcium channesl and better use as anti hypertensive to decrease vascular resistance
- what is the principal usefulness of calcium channel blockers?
- supraventricular arrhythmias and ventricular arrhythmias associated with acute MI due to Ca overload
- what are some class IV toxicities
- heart failure due to negative inotropy, hypotension due to excessive vasodiliation, heart block due to its decreas in conducting velocity, consitpation verapamil
- what is the treatment for torsades de pointes?
- correct hypokalemia, correct hypomagnesia, discontinue drugs the prolong qt interval, electrical pacing or drugs to shorten qt