FA pharm
Terms
undefined, object
copy deck
- maximal effect of a drug
- efficacy
- amt of drug needed for a given effect
- potency
- zero-order elimination
- phenytoin ethanol aspirin
- weak acids
- phenobarbital, methotrexate, TCAs, aspirin. treat OD with bicarb
- weak base
- amphetamines treat OD with NH4Cl
- redox, hydrolysis
- phase I lost first in elderly metabolites water soluble and often still active
- acetylation, glucuronidation, sulfation
- Phase II very polar, inactive metabolites excreted in urine
- Calculate loading dose.
- =Cp x Vd/F does NOT need to be changed in pts with impaired renal/hepatic fct
- Calculate maintenance dose.
- =Cp x CL/F must be LOWERED in pts with impaired liver/kidney fct
- Calculate Vd.
- = amt of drug in the body / plasma drug concentration
- Vd 4-8 L
- distribute in blood
- medium Vd
- distribute in extracellular space or body water
- Vd > body weight
- distribute in tissues
- Calculate CL.
- = rate of elimination of drug / plasma drug concentration = Vd x Ke (elimination constant)
- Calculate t1/2.
- = (0.7 x Vd) / CL drug reaches 94% of steady state after 4 half lives.
- A competitive antagonist shifts the curve ______, causing potency to _____.
- the right decrease
- A noncompetitive antagonist shifts the curve ________, causing efficacy to ______.
- downward decrease