Antifungal Antibiotics
Terms
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- Name serious systematic infections
- Cryptoccocal Meningitis, Pneumonia, Histoplasmosis, extrapulminary Blastomycosis, & Coccidiodoomycosis.
- Amphotericin B is paired with aspirin/aminophen why?
- To prevent a febrile reaction due to Amphotericin B side effects
- What is Ergosterol?
- A vital part in cell membranes of fungi that contain cholesterol.
- What are the side effects of Amphotericin B?
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Renal Toxicity, acute febrile reaction ( shaking chill), anemia & phlebitis
- How is Amphotericin B given?
- Intravenously
- What two antibiotics are given for serious systematic infections?
- Amphotericin B & Intracozole
- What antibiotics are given for less serious systemic infections?
- Oral azole drugs; Prototype is ketoconazole(fluconazole & itraconazole)
- What antibiotics are used for superficial fungal infections?
- Griseofulvin
- Name the azole drugs
- Clotrimazole and miconazole
- By adding different lipids to traditional Amphotericin B what is the first result?
- ABCD – Amphotericin B Colloidal Dispersion(Amphocil) - Ampho B + cholesterol sulfate causes rigor still occurs but less nephrotoxicity
- By adding different lipids to traditional Amphotericin B what is the second result?
- ABLC – Amphotericin B Lipid Complex - Ampho B + dimyristoylphosphatidyglycerols & toylphosphatidylcholines causes rigor still occurs but less nephrotoxicity
- What is phlebitis?
- Inflammation of the vein at the IV site
- How are the kidneys being monitored while taking Amphotericin B?
- By drawing creatinine levels