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Glossary of virulence factors

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exotoxins produced by
gram postiitve and negative
endotoxins produced by
gram NEGATIVE bacilli
how toxic are
exotoxins


endotoxins
exo = STRONGLY toxic

endo = not as much
site of toxin's effect

exo


endo
exo = specific mode is often obscure


endo = similar toxicity for most organs/cells
chemical nature of
endotoxins


exotoxins
exo: protein



endo: lipopolysaccharide
chemical nature of toxin secreted by endotoxins
cell-associated lps
how exotoxins are released


endotoxins?
exo: secreted


endo: remains bound; released when cell lyses
heat lability of

exotoxins


endotoxins
exo = heat-labile; easy to toxoid - inactivate.


endo = heat-stabile; don't inactivate.
host immune response to

exotoxins


endotoxins
exo: easy to neutralize w/ antibody


endo: hard to neutralize w/ antibody
do exotoxins produce fever/confusion in host?


do endo?
no



yes

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