Glossary of tubulointerstritial disease

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acute interstitial nephritis
acute renal failure, interstitial inflammatory cells, interstitial edema
mechanism of AIN
due to drugs, infections, or idopathic (most cases)
chronic interstitial nephritis
chronic renal failure, mixed inflammatory cells, tubular atrophy, fibrosis
mechanism of CIN
physical or chemical with precipitation of substances into medulla
ischemic due to drug induced vasc change
causes of CIn
drugs, NSAIDS, reflux nephropathy, stones, PCKD
acute pyelonephritis
infection involving parenchyma calyces and pelvis
causes of Acute pyelonephritis
ureteral reflux affects pelvis 95%
hematogenous infection affects cortex 5%
who is predisposed to acute pyelonephritis
pregnant women, diabets
chronic pyelonephritis with reflux nephropathy
multiple episodes of infection secondary to congenitally short intravesical ureter or obstruction
thyroidization tubular atrophy
chronic pyelonephritis with reflux nephropathy
acute tubular necrosis
acute renal failure secondary to tubular damge
causes of acute tubular necrosis
post transplant
phases of acute tubular necrosis
who is predisposed to papillary necrosis
long term analgesic users (acetominophen, phenacetin)
very large cystic kidneys, no dysplasia
large smooth kidneys, narrow cysts perpendicular to capsule
translucent systs on surface of cortex
benign simple cystic disease
no clinical significance
most common cause of abdominal mass in newborn
multicystic renal dysplasia
most common form of renal transplant rejection
acute cellular rejections
tubulitis, interstitial edema and inflammation
most common cause of graft loss
chronic allograft nephropathy
due to repeated subclinical episodes of acute cellular rejection
what causes characteristic nodular hyalinzation of arterioles and changes identical to chronic rejection?
calcineurin inhibitor toxicity

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