Glossary of phospholipid metabolism

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Structure of glycerophospholipids
Glycerol w/ fatty acid at C1 and C2
exchange group at phosphate
phosphatidic acid
beginning structure. Add to phosphate -OH to change into other glycerophospholipids.
need to produce surfactant.
w/ dificiency get dermatitus
can get arachadonic acid from
used in signal transduction.
broken down by Phospholipase C to form IP3 and DAG.
synthesis inhibited by lithium. contains arachadonic acid.
production of phosphotidylinositol, cardiolipin, phosphatidylglycerol
CTP-diacylglycerol is formed and binds glycerophospholipid.
production of phsphtidyl- choline, ethanolamine, serine
CTP binds head group, then combines with diacylglycerol and phospholipid
cytodine nucleotide
CTP is used to activate headgroups and DAG. CMP is released from reaction
Colleen Lakker
respiratory distress syndrome
6 week premature infant
not enough sufactant(surface tension)
Red Scaly dermititis
happens with choline deficiency
need 550 mg/day men
425 women
happens with total parenteral nutrition
Total parenteral nutrition
leads to choline dificiency
red scaly dermititus
Phospholipase A1
present in many tissues
removes FA from C1
Phospholipase A2
present in many mammalian tissues and pancreatic tissues
relases archodonic acid from phosphotidylinositol
is a proenzyme, and activated by trypsin
inhibited by glucocorticoids
inhibits Phosphoipase A2.
stops release of arachodonic acid
Phospholipase C
found in liver lysosomes and alpha toxin of clostridia and other bacilli
activated by the PIP2 system
plays a role in signal tranduction
produces IP3 and DAG from PIP2
cleaves the phosphate group
phosphotidylinositol/second messenger
PIP2 is cleaved by phospholipase C to produce IP3 and DAG.
IP3 binds with ER to cause release of Ca
Ca activates protein kinase C and DAG enhances activity
causes phosphorylation cascade
inhibits the production of phosphotidylinositole
inhibits the production of inisitol myo
Phosphotidylinositole degradation and recycling
inhibited by lithium
DAG to phosphotidic acid then activated with CTP
IP3 is converted to inositole myo

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