Glossary of phospholipid metabolism
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- Structure of glycerophospholipids
- Glycerol w/ fatty acid at C1 and C2
exchange group at phosphate
- phosphatidic acid
- beginning structure. Add to phosphate -OH to change into other glycerophospholipids.
need to produce surfactant.
w/ dificiency get dermatitus
can get arachadonic acid from
- used in signal transduction.
broken down by Phospholipase C to form IP3 and DAG.
synthesis inhibited by lithium. contains arachadonic acid.
- production of phosphotidylinositol, cardiolipin, phosphatidylglycerol
- CTP-diacylglycerol is formed and binds glycerophospholipid.
- production of phsphtidyl- choline, ethanolamine, serine
- CTP binds head group, then combines with diacylglycerol and phospholipid
- cytodine nucleotide
- CTP is used to activate headgroups and DAG. CMP is released from reaction
- Colleen Lakker
- respiratory distress syndrome
6 week premature infant
not enough sufactant(surface tension)
- Red Scaly dermititis
- happens with choline deficiency
need 550 mg/day men
happens with total parenteral nutrition
- Total parenteral nutrition
- leads to choline dificiency
red scaly dermititus
- Phospholipase A1
- present in many tissues
removes FA from C1
- Phospholipase A2
- present in many mammalian tissues and pancreatic tissues
relases archodonic acid from phosphotidylinositol
is a proenzyme, and activated by trypsin
inhibited by glucocorticoids
- inhibits Phosphoipase A2.
stops release of arachodonic acid
- Phospholipase C
- found in liver lysosomes and alpha toxin of clostridia and other bacilli
activated by the PIP2 system
plays a role in signal tranduction
produces IP3 and DAG from PIP2
cleaves the phosphate group
- phosphotidylinositol/second messenger
- PIP2 is cleaved by phospholipase C to produce IP3 and DAG.
IP3 binds with ER to cause release of Ca
Ca activates protein kinase C and DAG enhances activity
causes phosphorylation cascade
- inhibits the production of phosphotidylinositole
inhibits the production of inisitol myo
- Phosphotidylinositole degradation and recycling
- inhibited by lithium
DAG to phosphotidic acid then activated with CTP
IP3 is converted to inositole myo
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