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Glossary of pharm 4 2

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OH rings on SPMs
absence of one or both greatly increases oral effectiveness
- absence of both lets it cross BBB
alpha-carbon on SMPs
enhances resistance to MAO and increases oral effectiveness and duration
treating a SPM overdose
acidificaion of urine will protinate SPMs, which are usually weak bases
phenylephrine
- A agonist
- decongestion of MMs
- hypotension
- paroxysmal atrial tachycardia
- mydriasis
epinephrine
- A1 and B2 agonist
- vasoconstriction for local anesthesia
- control of hemorrhage
- hemostasis during surgery
- main drug for TIHR, esp w/ cardiac arrest and glaucoma
ephedrine
- A agonist
- hypotension
- stress incontinence
albuterol
- B2-receptor selective agonist
- used to treat asthma b/c it relaxes bronchial SM
salmeterol
- B2-receptor selective agonist
- used to treat asthma b/c it relaxes bronchial SM
isoproterenol
- B-receptor selective agonist
- used to treat asthma b/c it relaxes bronchial SM
isoproterenol trade names
Isuprel
acute anaphylactic Type I hypersensitivity reactions
- antigens (bee venom, penicillin) evoke production of IgE that fixes to mast cells -> whole cascade
- vasodilation, vaso perm, edema, SM contration or relaxation can lead to death
EPI in TIHR
- B2 receptor activation on mast cells increases cAMP levels and prevents degranulation
- A1 receptor activation supports blood pressure and prevents suffocation
dobutamine
- acute heart failure in TIHR
Dopamine use
circulatory shock
amphetamine
- CNS Active Phenylethylamines
- attention deficit hyperactivity disorder
dobutamine trade name
- Dobutrex

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