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Glossary of muscle relaxants 4-17-06

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neuromuscular blocking drugs are used for
muscle paralysis in surgery or mechanical ventilation
name a depolarising neurmuscular blocking drug
succinylcholine
name 6 nondepolarizing neuromuscular blocking drugs
tubocurarine
*mnemonic -- the "cur" drugs are nondepolarizing neuromuscular blocking agents, name 5
atracurium, mivacurium, pancuronium, vecuronium, rapacuronium
is succinylcholine depolarizing or nondepolarizing?
depolarizing
is tubocurarine depolarizing or nondepolarizing?
nondepolarizing
is atracurium depolarizing or nondepolarizing?
nondepolarizing
is mivacurium depolarizing or nondepolarizing?
nondepolarizing
is pancuronium depolarizing or nondepolarizing?
nondepolarizing
is vacuronium depolarizing or nondepolarizing?
nondepolarizing
is rapacuronium depolarizing or nondepolarizing?
nondepolarizing
what is tubocurarine used for
nondepolarizing neuromuscular blockade
what agents are used to reverse neuromuscular blockade by succinylcholine?
cholinesterase inhibitors in phase II (ex -- neostigmine)
what phase of succinylcholine neuomuscular bloackade is reversible?
phase II (repolarized but blocked)
what agents are used to reverse pahse I neuromuscular blockade by succinylcholine?
phase I Succinylcholine neuromuscular blockade cannot be reversed
what phase of succinylcholine neuomuscular bloackade is irreversible?
phase I Succinylcholine neuromuscular blockade cannot be reversed
what is atracurium used for
nondepolarizing neuromuscular blockade
what is the effect of cholinesterase inhibitors on succinylcholine neuromuscular blockade?
phase I: cholinesterase inhibitors potentiates the blockade phase II: cholinesterase inhibitors reverse the blockade
what cholinesterase inhibitor is used to reverse phase II of succinylcholine neuromuscular blockade?
neostigmine
what is mivacurium used for
nondepolarizing neuromuscular blockade
what is dantrolene used for
treat malignant hyperthermia and neuroleptic malignant syndrome
what causes malignant hyperthermia
use inhalation anesthetics and succinylcholine together
what inhalation anesthetic DOES NOT cause malignanat hyperthermia?
N2O
what is neuroleptic malignant syndrome
a toxicity of antipsychotic drugs
what drug is used to treat malignant hyperthermia
dantrolene
what is the mechanism of dantrolene
prevents release of Ca++ from saarcoplasmic reticulum of skeletal muscle

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