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Glossary of hyperlipidemia and atherosclerosis

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atherosclerosis
disease of vasculature in large and medium sized arteries; leads to heart attack
process of atheros. (1)
elevated LDL
process athero. (2)
endothelial cells respond to compensate for injury
process athero. (3)
monocytes go to macrophages, then foam cells
process athero. (4)
smooth muscle cells migrate into lesion--forms thrombus
process athero. (5)
secrete growth factors and cytokines, fibrous cap that walls off the lesion from the lumen
chylomicron
from fatty acids of dietary tg's and cholesterol
VLDL
very low density lipoproteins, endogenous or hepatocyte tg's
VLDL remnants
IDL; re-enter the circulation, some then converted to LDL
ApoB-100
apoprotein of LDL, ligand that binds LDL to receptor
HDL
under 40 is low
abnormal lipid transport
-high LDL
-low HDL
-high tg's
total cholesterol
less than 200
LDL
less than 100
tg's
less than 150
STATINS
HMG-CoA reductase inhibitors, less cholesterol, removes LDL from blood
statin SE's
hepatotoxicity, myopathy
Bile-acid binding resins (cholestipol and cholestyramine)
bind to neg charged bile acids, excretes cholesterol
Bile-acid binding resins SE's
gi upset, binds to other drugs
Niacin
B-complex vitamin, increases HDL, lowers LDL, inhibits lipolysis of tg's
Fibrates
interacts with PPARs, more clearance of tg's
ezetimibe
inhibits dietary cholesterol uptake by enterocytes

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