hemepath intro
Terms
undefined, object
copy deck
- Reactive Conditions Causing Lymphadenopathy
- Infectious causes, Drug Reactions, Connective Tissue Disorders
- Features of Reactive Lymphadenitis
- 1 Partially distort lymph node architecture 2 Often limited to certain lymph node groups 3 May have a distinctive histologic pattern
- Cat Scratch Disease causitive organism
- Bartonella henselae
- Toxoplasmosisn
- Classic Triad 1 Follicular hyperplasia 2 Epithelioid histiocytes impinging on germinal centers 3 Monocytoid B cell hyperplasia (i) B cells in the sinuses with a lot of cytoplasm (ii) “fried egg†appearance
- Infectious Mononucleosis pathological appearance
- 1 Expansion of the paracortex (T cell zone) 2 “moth-eaten†appearance 3 Scattered large immunoblasts among small T cells 4 Reactive atypical lymphocytes in the peripheral blood
- Cat Scratch Disease microscopic appearancen
- 1 Follicular hyperplasia 2 Stellate microabscesses 3 Necrotizing granulomas with lots of neutrophils
- Solid Tumors vs HP Neoplasms
- Solid Tumors: Carcinomas and sarcomas.Characterized by: 1Localized growth 2 Invasion 3 Metastasis HP Neoplasms: Leukemias and lymphomas. Characterized by: 1 Systemic disease 2 Replacement of normal marrow or lymph node elements 3Circulating tumor cells in the peripheral blood
- Acute vs. Chronic Leukemias
- Chronic Composed of more
- Lymphoma Classification (Hodgkin vs Non H)
- Hodgkin Lymphoma 1 Less common, 2 Pleomorphic growth pattern 3 Neoplastic cell is rare Non-Hodgkin Lyphomas 1 More commmon 2 Usually have a monomorphic growth pattern, 3 neoplastic cell = predominant cell
- Follicular Lymphoma
- 1 Peripheral B cell lymphoma; 2 Morphology & immunophenotype reminiscent of germinal center B cells; (i) Nodular follicular architecture; (iii) Small cleaved lymphocytes
- Transformation
- A change in histologic appearance and clinical behavior from an indolent process to a more aggressive neoplasm
- Diagnosing Hematolymphoid Disordersn
- Step 1: History & Physical Step 2: Draw blood, Laboratory testing guided by H&P Step 3: get tissue; Peripheral blood, bone marrow, lymph node Step 4:Morphology, Immunophenotype, Cytogenetic and Molecular Analysis